Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output.

Autor: Dimasi CG; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Lazniewska J; Mechanisms in Cell Biology and Disease Research Group, UniSA Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia., Plush SE; Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia.; Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Saini BS; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Holman SL; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Cho SKS; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Wiese MD; Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Sorvina A; Mechanisms in Cell Biology and Disease Research Group, UniSA Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia., Macgowan CK; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Seed M; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Brooks DA; Mechanisms in Cell Biology and Disease Research Group, UniSA Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia., Morrison JL; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Darby JRT; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2021 Dec; Vol. 14 (12), pp. e202100157. Date of Electronic Publication: 2021 Sep 16.
DOI: 10.1002/jbio.202100157
Abstrakt: Intrauterine growth restriction (IUGR) is a result of limited substrate supply to the developing fetus in utero, and can be caused by either placental, genetic or environmental factors. Babies born IUGR can have poor long-term health outcomes, including being at higher risk of developing cardiovascular disease. Limited substrate supply in the IUGR fetus not only changes the structure of the heart but may also affect metabolism and function of the developing heart. We have utilised two imaging modalities, two-photon microscopy and phase-contrast MRI (PC-MRI), to assess alterations in cardiac metabolism and function using a sheep model of IUGR. Two-photon imaging revealed that the left ventricle of IUGR fetuses (at 140-141 d GA) had a reduced optical redox ratio, suggesting a reliance on glycolysis for ATP production. Concurrently, the use of PC-MRI to measure foetal left ventricular cardiac output (LVCO) revealed a positive correlation between LVCO and redox ratio in IUGR, but not control fetuses. These data suggest that altered heart metabolism in IUGR fetuses is indicative of reduced cardiac output, which may contribute to poor cardiac outcomes in adulthood.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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