| Autor: |
Tham PT; Hanoi University of Industry, Hanoi, Vietnam., Chinh PT; Thai Nguyen University of Sciences, Thai Nguyen, Vietnam., Thang DX; Hanoi University of Industry, Hanoi, Vietnam., An NTK; Hanoi University of Industry, Hanoi, Vietnam., Van Tuyen N; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Anh LT; Central Institute for Natural Resources and Environmental Studies, Vietnam National University, Hanoi, Vietnam., Van Doan V; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Yen PH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Nhiem NX; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Van Kiem P; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Tai BH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam. |
| Abstrakt: |
A new muurolane-type sesquiterpene, a new flavone arabinofuranoside derivative, and other five known flavone arabinofuranoside derivatives were isolated from the leaves of Fissistigma bicolor (Annonaceae family). Their chemical structures were determined to be (1 S ,6 R ,7 S )-muurola-4,10(14)-diene-15-ol ( 1 ), quercetin 3- O - β -D-apiofuranosyl-(1→2)- α -L-arabinofuranoside ( 2 ), quercetin 3- O - α -L-rhamnopyranosyl-(1→2)- α -L-arabinofuranoside ( 3 ), quercetin 3- O - α -L-arabinofuranoside ( 4 ), kaempferol 3- O - β -D-apiofuranosyl-(1→2)- α -L-arabinofuranoside ( 5 ), kaempferol 3- O - α -L-rhamnopyranosyl-(1→2)- α -L-arabinofuranoside ( 6 ), and kaempferol 3- O - α -L-arabinofuranoside ( 7 ) by analyses of HR-ESI-MS and NMR spectral data. Compounds 4 and 7 containing monosaccharide, arabinofuranoside, potentially inhibited NO productions in LPS activated RAW264.7 cells (IC 50 13.4 ± 0.5 and 12.6 ± 0.4 µM) in compared to disaccharide derivatives (IC 50 ranging from 58.9 ± 3.3 to 65.6 ± 3.8 µM). |
