| Autor: |
Paściak A; Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland., Pilch-Wróbel A; Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland., Marciniak Ł; Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland., Schuck PJ; Department of Mechanical Engineering, Columbia University, New York, New York 10027, United States., Bednarkiewicz A; Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Sep 22; Vol. 13 (37), pp. 44556-44567. Date of Electronic Publication: 2021 Sep 09. |
| DOI: |
10.1021/acsami.1c12409 |
| Abstrakt: |
Localized photothermal therapy (PTT) has been demonstrated to be a promising method of combating cancer, that additionally synergistically enhances other treatment modalities such as photodynamic therapy or chemotherapy. PTT exploits nanoparticles (called nanoheaters), that upon proper biofunctionalization may target cancerous tissues, and under light stimulation may convert the energy of photons to heat, leading to local overheating and treatment of cancerous cells. Despite extensive work, there is, however, no agreement on how to accurately and quantitatively compare light-to-heat conversion efficiency (η Q ) and rank the nanoheating performances of various groups of nanomaterials. This disagreement is highly problematic because the obtained η Q values, measured with various methods, differ significantly for similar nanomaterials. In this work, we experimentally review existing optical setups, methods, and physical models used to evaluate η Q . In order to draw a binding conclusion, we cross-check and critically evaluate the same Au@SiO 2 sample in various experimental conditions. This critical study let us additionally compare and understand the influence of the other experimental factors, such as stirring, data recording and analysis, and assumptions on the effective mass of the system, in order to determine η Q in a most straightforward and reproducible way. Our goal is therefore to contribute to the understanding, standardization, and reliable evaluation of η Q measurements, aiming to accurately rank various nanoheater platforms. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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