Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
| Autor: | Santos AAN; Institute of Biology, Federal University of Bahia, Salvador, Brazil., Ribeiro PDS; Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil., da França GV; Institute of Biology, Federal University of Bahia, Salvador, Brazil., Souza FN; Institute of Collective Health, Federal University of Bahia, Salvador, Brazil., Ramos EAG; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Brazil., Figueira CP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Brazil., Reis MG; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Brazil.; Faculty of Medicine of Bahia, Federal University of Bahia, Salvador, Brazil.; Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, Connecticut, United States of America., Costa F; Institute of Collective Health, Federal University of Bahia, Salvador, Brazil., Ristow P; Institute of Biology, Federal University of Bahia, Salvador, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Sep 08; Vol. 15 (9), pp. e0009736. Date of Electronic Publication: 2021 Sep 08 (Print Publication: 2021). |
| DOI: | 10.1371/journal.pntd.0009736 |
| Abstrakt: | Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs. Competing Interests: The authors have declared that no competing interests exist. |
| Databáze: | MEDLINE |
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