Autism Spectrum Disorders: Etiology and Pathology

Autor:	Sauer AK; Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland; Bernal Institute, University of Limerick, Limerick, Ireland, Stanton JE; Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland; Bernal Institute, University of Limerick, Limerick, Ireland, Hans S; Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland, Grabrucker AM; Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland; Bernal Institute, University of Limerick, Limerick, Ireland; Health Research Institute (HRI), University of Limerick, Limerick, Ireland
Jazyk:	angličtina
Zdroj:	2021 Aug 20.
DOI:	10.36255/exonpublications.autismspectrumdisorders.2021
Abstrakt:	Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases. The cause of ASD is unknown, but several genetic and non-genetic risk factors have been characterized that, alone or in combination, are implicated in the development of ASD. Currently, no diagnostic biomarkers are available, and the diagnosis of ASD is based on typical features that include repetitive behaviors, and impaired social communication and interaction. Several pathomechanisms such as alterations in brain development and function, and synaptic defects have been proposed to contribute to these behaviors. In addition, processes outside the central nervous system may contribute to, or modify, the clinical phenotype and severity. This chapter summarizes the clinical features of ASD, highlights the important genetic and non-genetic risk factors for ASD, and introduces the current knowledge around the pathological processes within and outside the brain. (Copyright: The Authors.)
Databáze:	MEDLINE
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