Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil.

Autor:	Monteiro MJSD; Universidade Federal do Piauí, Mestrado em Ciências e Saúde, Teresina, PI, Brasil., Silva MNPD; Universidade Federal do Piauí, Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Teresina, PI, Brasil., Paiva AA; Universidade Federal do Piauí, Departamento de Nutrição, Teresina, PI, Brasil., Marreiro DDN; Universidade Federal do Piauí, Departamento de Nutrição, Teresina, PI, Brasil., Luzia LA; Universidade de São Paulo, Laboratório de Micronutrientes, São Paulo, SP, Brasil., Henriques GS; Universidade Federal de Minas Gerais, Escola de Enfermagem, Laboratório Experimental de Nutrição, Belo Horizonte, MG, Brasil., Rondó PHC; Universidade de São Paulo, Departamento de Nutrição, Escola de Saúde Pública, São Paulo, SP, Brasil., Sene IS; Universidade Federal do Piauí, Laboratório de Pesquisas em Leishmanioses, Teresina, PI, Brasil.; Laboratório de Anatomia Patológica e Biologia Molecular, Teresina, PI, Brasil., Almeida ATA; Universidade Federal do Piauí, Curso de Farmácia, Teresina, PI, Brasil., Costa CHN; Universidade Federal do Piauí, Laboratório de Pesquisas em Leishmanioses, Teresina, PI, Brasil.; Centro de Inteligência para Agravos Tropicais Emergentes e Negligenciados, Teresina, PI, Brasil.; Universidade Federal do Piauí, Departamento de Medicina Comunitária, Teresina, PI, Brasil., Costa DL; Universidade Federal do Piauí, Laboratório de Pesquisas em Leishmanioses, Teresina, PI, Brasil.; Centro de Inteligência para Agravos Tropicais Emergentes e Negligenciados, Teresina, PI, Brasil.; Universidade Federal do Piauí, Departamento Materno-Infantil, Teresina, PI, Brasil.
Jazyk:	angličtina
Zdroj:	Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2021 Sep 06; Vol. 54, pp. e08002020. Date of Electronic Publication: 2021 Sep 06 (Print Publication: 2021).
DOI:	10.1590/0037-8682-0800-2020
Abstrakt:	Introduction: Malnutrition and kala-azar (or visceral leishmaniasis) are significant public health problems in different parts of the world. Immunity and susceptibility to infectious and parasitic diseases are directly linked to the host's nutritional state, but little is known about the interaction between nutrition and kala-azar. This study aimed to evaluate nutritional status with kala-azar and correlate these findings with the clinical and laboratory manifestations of the disease, and zinc and retinol levels. Methods: This was a cross-sectional study of 139 patients with kala-azar. Nutritional status classification was performed according to international recommendations. Parametric or nonparametric tests were applied whenever indicated in a two-sided test with a 5% significance level. Results: Weight loss and malnutrition were more frequent in adults. Body mass index-for-age, fat area of the arm, and upper arm muscle area were significantly associated with probability of death. The presence of human immunodeficiency virus, hepatomegaly, and splenomegaly was correlated with nutritional assessment. Blood leukocyte and lymphocyte, serum creatine, and vitamin A levels were significantly higher in adult men. Vitamin A levels were highly associated with the level of hemoglobin and C-reactive protein (CRP) in multivariate analysis. All patients had reduced plasma zinc levels, but this finding had no association with the outcome variables. Conclusions: Malnutrition was correlated with severe disease and was more prevalent in older people with kala-azar. Vitamin A deficiency was associated with hemoglobin and CRP. Zinc levels were reduced in patients with kala-azar.
Databáze:	MEDLINE
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