Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial.

Autor:	Costa RR; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Vieira AF; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Coconcelli L; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Fagundes AO; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Buttelli ACK; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Pereira LF; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Stein R; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS - Brasil., Kruel LFM; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2021 Aug; Vol. 117 (2), pp. 270-278.
DOI:	10.36660/abc.20200197
Abstrakt:	Background: Statin use is highlighted as the most commonly utilized therapy for the treatment of dyslipidemias and can be considered as the most efficient pharmacological intervention for low-density lipoprotein (LDL) reduction. On the other hand, physical training can be considered an efficient and safe non-pharmacological strategy to promote improvements in lipid profile. However, the influence of statins on lipid adaptations arising from water-based training in populations with dyslipidemia is not known. Objectives: To analyze the influence of simvastatin use on lipid adaptations arising from water-based aerobics and resistance training in elderly women with dyslipidemia. Methods: Sixty-nine elderly (66.13 ± 5.13 years), sedentary, and dyslipidemic women, both non-users and users of simvastatin (20 mg and 40 mg), were randomized into the following 3 groups: water-based aerobic training (WA), water-based resistance training (WR), and control group (CG). Total duration of interventions, for all experimental groups consisted of 10 weeks, with 2 weekly sessions. Biochemical analyses were performed before the beginning of the interventions and repeated after the end of the trial. Generalized estimating equations were used to compare these data, setting α = 0.05. Results: In intention-to-treat analysis, the medicated participants obtained a greater magnitude of decrease in total cholesterol (TC) (-3.41 to -25.89 mg.dl-1; p = 0.038), LDL (-5.58 to -25.18 mg.dl-1; p = 0.007) and TC/HDL ratio (-0.37 to -0.61; p = 0.022) when compared to the non-medicated participants, and this decrease was statistically significant only in the WR group. Conclusions: Statin use enhances the adaptations promoted by water-based physical training in CT, LDL levels, and CT/HDL ratio, and it is more pronounced after WR.
Databáze:	MEDLINE
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