In vitro investigations with selective adsorbents for IgE and IgM.

Autor: Behm E; Department of Internal Medicine, Wilhelm-Pieck-University, Rostock, GDR., Kuroda T, Yamawaki N, Tsuda N, Loth F, Schwachula G, Sabrowski E, Falkenhagen D, Klinkmann H
Jazyk: angličtina
Zdroj: Biomaterials, artificial cells, and artificial organs [Biomater Artif Cells Artif Organs] 1987; Vol. 15 (1), pp. 101-11.
DOI: 10.3109/10731198709118511
Abstrakt: In vitro studies were carried out with IM-T. This adsorbent consists of polyvinyl alcohol joined with tryptophan side chains and was delivered by ASAHI Medical Co., Ltd., Tokyo/Japan. It was found that IM-T binds immunoglobulins G and M and also immune complexes only moderately but IgE was adsorbed in remarkable amounts. A clear dose-dependent was adsorbed in remarkable amounts. A clear dose-dependent manner of the IgE adsorption could be stated. Kinetic studies revealed that the binding was only slow and gradual.
Databáze: MEDLINE