Prolonged Consumption of Sweetened Beverages Lastingly Deteriorates Cognitive Functions and Reward Processing in Mice.

Autor:	Hamelin H; Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91190, Gif-ur-Yvette, France., Poizat G; Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91190, Gif-ur-Yvette, France., Florian C; Research Center on Animal Cognition (CRCA), Center for Integrative Biology, CNRS UMR 5169, Toulouse 31062, France., Kursa MB; Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, 02-106 Warsaw, Poland., Pittaras E; Stanford University, Heller Laboratory, Stanford, CA 94305-5020, USA., Callebert J; Service of Biochemistry and Molecular Biology, INSERM U942, Hospital Lariboisière, APHP, Paris 75010, France., Rampon C; Research Center on Animal Cognition (CRCA), Center for Integrative Biology, CNRS UMR 5169, Toulouse 31062, France., Taouis M; Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91190, Gif-ur-Yvette, France., Hamed A; Laboratory of Spatial Memory, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland., Granon S; Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91190, Gif-ur-Yvette, France.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2022 Mar 30; Vol. 32 (7), pp. 1365-1378.
DOI:	10.1093/cercor/bhab274
Abstrakt:	We investigated the detrimental effects of chronic consumption of sweet or sweetened beverages in mice. We report that consumption of beverages containing small amounts of sucrose during several weeks impaired reward systems. This is evidenced by robust changes in the activation pattern of prefrontal brain regions associated with abnormal risk-taking and delayed establishment of decision-making strategy. Supporting these findings, we find that chronic consumption of low doses of artificial sweeteners such as saccharin disrupts brain regions' activity engaged in decision-making and reward processes. Consequently, this leads to the rapid development of inflexible decisions, particularly in a subset of vulnerable individuals. Our data also reveal that regular consumption, even at low doses, of sweet or sweeteners dramatically alters brain neurochemistry, i.e., dopamine content and turnover, and high cognitive functions, while sparing metabolic regulations. Our findings suggest that it would be relevant to focus on long-term consequences on the brain of sweet or sweetened beverages in humans, especially as they may go metabolically unnoticed. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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