Investigating the impact of COVID-19 lockdown on adults with a recent history of recurrent major depressive disorder: a multi-Centre study using remote measurement technology.

Autor:	Leightley D; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. daniel.leightley@kcl.ac.uk., Lavelle G; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., White KM; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Sun S; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Matcham F; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ivan A; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Oetzmann C; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Penninx BWJH; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Lamers F; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Siddi S; Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain., Haro JM; Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain., Myin-Germeys I; Center for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium., Bruce S; RADAR-CNS Patient Advisory Board, King's College London, London, UK., Nica R; RADAR-CNS Patient Advisory Board, King's College London, London, UK.; Romanian League for Mental Health, London, UK., Wickersham A; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Annas P; H. Lundbeck A/S, Copenhagen, Denmark., Mohr DC; Center for Behavioral Intervention Technologies, Northwestern University, Chicago, USA., Simblett S; King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK., Wykes T; King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK., Cummins N; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Chair of Embedded Intelligence for Health Care & Wellbeing, University of Augsburg, Augsburg, Germany., Folarin AA; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK.; Institute of Health Informatics, University College London, London, UK., Conde P; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ranjan Y; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Dobson RJB; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Maudsley Biomedical Research Centre, National Institute for Health Research, South London and Maudsley NHS Foundation Trust, London, UK., Narayan VA; Janssen Research and Development, LLC, Titusville, NJ, USA., Hotopf M; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Maudsley Biomedical Research Centre, National Institute for Health Research, South London and Maudsley NHS Foundation Trust, London, UK.
Jazyk:	angličtina
Zdroj:	BMC psychiatry [BMC Psychiatry] 2021 Sep 06; Vol. 21 (1), pp. 435. Date of Electronic Publication: 2021 Sep 06.
DOI:	10.1186/s12888-021-03434-5
Abstrakt:	Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes a clinical illness Covid-19, has had a major impact on mental health globally. Those diagnosed with major depressive disorder (MDD) may be negatively impacted by the global pandemic due to social isolation, feelings of loneliness or lack of access to care. This study seeks to assess the impact of the 1st lockdown - pre-, during and post - in adults with a recent history of MDD across multiple centres. Methods: This study is a secondary analysis of an on-going cohort study, RADAR-MDD project, a multi-centre study examining the use of remote measurement technology (RMT) in monitoring MDD. Self-reported questionnaire and passive data streams were analysed from participants who had joined the project prior to 1st December 2019 and had completed Patient Health and Self-esteem Questionnaires during the pandemic (n = 252). We used mixed models for repeated measures to estimate trajectories of depressive symptoms, self-esteem, and sleep duration. Results: In our sample of 252 participants, 48% (n = 121) had clinically relevant depressive symptoms shortly before the pandemic. For the sample as a whole, we found no evidence that depressive symptoms or self-esteem changed between pre-, during- and post-lockdown. However, we found evidence that mean sleep duration (in minutes) decreased significantly between during- and post- lockdown (- 12.16; 95% CI - 18.39 to - 5.92; p <  0.001). We also found that those experiencing clinically relevant depressive symptoms shortly before the pandemic showed a decrease in depressive symptoms, self-esteem and sleep duration between pre- and during- lockdown (interaction p = 0.047, p = 0.045 and p <  0.001, respectively) as compared to those who were not. Conclusions: We identified changes in depressive symptoms and sleep duration over the course of lockdown, some of which varied according to whether participants were experiencing clinically relevant depressive symptoms shortly prior to the pandemic. However, the results of this study suggest that those with MDD do not experience a significant worsening in symptoms during the first months of the Covid - 19 pandemic. (© 2021. The Author(s).)
Databáze:	MEDLINE
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