| Autor: |
Nikulin AD; Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. nikulin@vega.protres.ru. |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2021 Aug; Vol. 86 (8), pp. 1025-1040. |
| DOI: |
10.1134/S0006297921080125 |
| Abstrakt: |
The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA-protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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