Correlation of hair cortisol and interleukin 6 with structural change in the active progression of keratoconus.

Autor:	Stival LR; From the Department of Ophthalmology at University of Sao Paulo, Sao Paulo, Brazil (Stival, Santhiago); Department of Ophthalmology at Federal University of Goias, Goiania, Brazil (Stival, Avila, Chaves, Toledo); Department of Computer Science at Federal University of Minas Gerais, Belo Horizonte, Brazil (Araujo); Nucleus of Toxicopharmacological Studies and Research-NEPET, Faculty of Pharmacy, Federal University of Goias, Goiania, Brazil (Silva, Cunha); Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil (Oliveira)., Avila LP, Araujo DC, Chaves LF, Toledo MC, Silva AC, Cunha LC, Oliveira TF, Santhiago MR
Jazyk:	angličtina
Zdroj:	Journal of cataract and refractive surgery [J Cataract Refract Surg] 2022 May 01; Vol. 48 (5), pp. 591-598.
DOI:	10.1097/j.jcrs.0000000000000809
Abstrakt:	Purpose: To evaluate interleukin (IL) and hair cortisol concentrations (HCCs) in progressive keratoconus (KC) and compare them with KC-stable eyes and healthy control, and to determine the correlation of these inflammatory mediators and HCCs and their relationship with structural damage represented by increased corneal curvature. Setting: University of Sao Paulo, Brazil. Design: Prospective observational comparative study. Methods: 133 eyes of 74 patients were included. The concentrations of tear cytokines: IL1B, IL6, IL8, IL10, IL12p70, and tumor necrosis factor α were obtained by capillary flow and measured using a flow cytometer. HCCs were determined from the most proximal hair segment as an index of cumulative secretion and measured by liquid chromatography mass spectrometry. Results: 133 eyes of 74 patients. Only IL6 was increased in progressive KC tears compared with stable KC (6.59 ± 3.25 pg/mL vs 4.72 ± 1.91 pg/mL; P < .0001) with a positive correlation between IL6 and maximum keratometry (Kmax) (P < .0001). Progressive KC exhibited significantly higher HCC than stable KC (0.624 ± 0.160 ng/mg vs 0.368 ± 0.0647 ng/mg; P < .0001) and healthy controls (0.624 ± 0.160 ng/mg vs 0.351 ± 0.0896 ng/mg; P < .0001). There was a significant correlation between HCC and Kmax (P < .0001). Conclusions: KC eyes that are progressing have a higher concentration of IL6 and long-term cortisol than patients with stable forms of KC; second, there is a significant correlation between this increase in IL6 and cortisol with corneal structural damage. Finally, there is a meaningful relationship between this interleukin and the previous few months' cortisol levels. (Copyright © 2021 Published by Wolters Kluwer on behalf of ASCRS and ESCRS.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu