Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism.

Autor:	Marinho PS; Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., da Cunha AJLA; Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Chimelli L; Laboratory of Neuropathology, Rio de Janeiro State Brain Institute, Rio de Janeiro, Brazil., Avvad-Portari E; Department of Pathological Anatomy, Fernandes Figueira Institute, Fiocruz, Rio de Janeiro, Brazil.; School of Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Andreiuolo FDM; Laboratory of Neuropathology, Rio de Janeiro State Brain Institute, Rio de Janeiro, Brazil., de Oliveira-Szejnfeld PS; Diagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.; Diagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Mendes MA; Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Gomes IC; Genetics Department, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Anatomic Pathology Service, Jesus Municipal Hospital, Rio de Janeiro, Brazil., Souza LRQ; Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Guimarães MZ; Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Department of Phamacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Goldman SM; Diagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil., de Oliveira MBG; Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Rehen S; Diagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Amim J Jr; Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Tovar-Moll F; Diagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.; Diagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Prata-Barbosa A; Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2021 Aug 16; Vol. 8, pp. 677001. Date of Electronic Publication: 2021 Aug 16 (Print Publication: 2021).
DOI:	10.3389/fmed.2021.677001
Abstrakt:	SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Marinho, da Cunha, Chimelli, Avvad-Portari, Andreiuolo, de Oliveira-Szejnfeld, Mendes, Gomes, Souza, Guimarães, Goldman, de Oliveira, Rehen, Amim, Tovar-Moll and Prata-Barbosa.)
Databáze:	MEDLINE
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