Comparative effects of combined use of alcohol with cannabis and tobacco on testicular function in rats.

Autor:	Nwonuma CO; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Osemwegie OO; Department of Microbiology, Landmark University, Omu-aran, Nigeria., Irokanulo EO; Department of Microbiology, Landmark University, Omu-aran, Nigeria., Alejolowo OO; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Kayode OT; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Olaolu TD; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Ada AS; Department of Veterinary Physiology and Biochemistry, University Ilorin, Ilorin 240003, Nigeria., Rotimi DE; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Maimako RF; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Adedayo AS; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria., Ojo OA; Department of Biochemistry, Landmark University, Omu-aran 370102, Nigeria.
Jazyk:	angličtina
Zdroj:	Toxicology research [Toxicol Res (Camb)] 2021 Jun 29; Vol. 10 (4), pp. 761-770. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
DOI:	10.1093/toxres/tfab060
Abstrakt:	Alcoholism has been linked to problems with male reproductive function. The combined effects of alcohol, cannabis, and tobacco were compared in this study. A total of 35 rats were assigned randomly into seven groups A-G: animals in A were administered distilled water. Animals in B-G were either administered alcohol orally (30 ml 40% alcohol) or exposed to smoke from ignited tobacco (exposure to smoke from 0.7 g tobacco for 5 min) or cannabis (exposure to smoke from 0.7 g tobacco and cannabis for 5 min): B (orally administered alcohol), C (exposed to the smoke from tobacco), D (exposed to smoke from cannabis), E (treated with alcohol and exposed to smoke from tobacco), F (treated with alcohol and exposed to smoke from cannabis), G (treated with alcohol and exposed to smokes from tobacco and cannabis). Assays were carried on the testicular homogenate after a 14-day treatment. There was a significant increase in activity of alkaline phosphatase ( P  ≤ 0.05), concentrations of cholesterol, glutathione reductase, and malondialdehyde in treated rats by the co-administration of alcohol with cannabis and tobacco compared with the control group. The combined treatment also caused degeneration and morphological distortions of testicular cells. The biochemical and histoarchitectural change was due to oxidative damage attributable to the synergistic effects. The high binding energy of tetrahydrocannabinol ligand to prostate acid phosphatase may be a prediction that the ligand can have an inhibitory effect on the function of enzymes in the prostate. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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