Clinical Profile of Neonates Admitted with Sepsis to Neonatal Intensive Care Unit of Jimma Medical Center, A Tertiary Hospital in Ethiopia.

Autor: Berhane M; Department of Pediatrics and Child Health, Jimma University., Gidi NW; Department of Pediatrics and Child Health, Jimma University., Eshetu B; Department of Pediatrics and Child Health, Jimma University., Gashaw M; Department of Medical Laboratory Sciences, Jimma University., Tesfaw G; Department of Medical Laboratory Sciences, Jimma University., Wieser A; Max von Pettenkofer-Institute, Ludwig-Maximilians-Universität (LMU), Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität (LMU), Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Germany., Bårnes GK; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.; Innlandet Hospital Trust, Division Gjøvik-Lillehammer, Gjøvik, Norway., Froeschl G; Division of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität (LMU), Munich, Germany., Ali S; Department of Microbiology, St. Paul Hospital Millennium Medical College., Gudina EK; Department of Internal Medicine, Jimma University.
Jazyk: angličtina
Zdroj: Ethiopian journal of health sciences [Ethiop J Health Sci] 2021 May; Vol. 31 (3), pp. 485-494.
DOI: 10.4314/ejhs.v31i3.5
Abstrakt: Background: Globally, over 3 million newborn die each year, one million of these attributed to infections. The objective of this study was to determine the etiologies and clinical characteristics of sepsis in neonates admitted to intensive care unit of a tertiary hospital in Ethiopia.
Methods: A longitudinal hospital based cohort study was conducted from April 1 to October 31, 2018 at the neonatal intensive care unit of Jimma Medical Center, southwest Ethiopia. Diagnosis of sepsis was established using the World Health Organization's case definition. Structured questionnaires and case specific recording formats were used to capture the relevant data. Venous blood and cerebrospinal fluid from neonates suspected to have sepsis were collected.
Results: Out of 304 neonates enrolled in the study, 195 (64.1%) had clinical evidence for sepsis, majority (84.1%; 164/195) of them having early onset neonatal sepsis. The three most frequent presenting signs and symptoms were fast breathing (64.6%; 122/195), fever (48.1%; 91/195) and altered feeding (39.0%; 76/195). Etiologic agents were detected from the blood culture of 61.2% (115/195) neonates. Bacterial pathogens contributed for 94.8% (109/115); the rest being fungal etiologies. Coagulase negative staphylococci (25.7%; 28/109), Staphylococcus aureus (22.1%; 24/109) and Klebsiella species (16.5%; 18/109) were the most commonly isolated bacteria.
Conclusion: Majority of the neonates had early onset neonatal sepsis. The major etiologies isolated in our study markedly deviate from the usual organisms causing neonatal sepsis. Multicentre study and continuous surveillance are essential to tackle the current challenge to reduce neonatal mortality due to sepsis in Ethiopia.
(© 2021 Melkamu B, et al.)
Databáze: MEDLINE
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