Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models.
| Autor: | Sanz-Blasco R; Department of Experimental Psychology, Complutense University of Madrid (UCM), Madrid, Spain., Ruiz-Sánchez de León JM; Department of Experimental Psychology, Complutense University of Madrid (UCM), Madrid, Spain., Ávila-Villanueva M; Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Queen Sofía Foundation Alzheimer Center, Madrid, Spain., Valentí-Soler M; Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Queen Sofía Foundation Alzheimer Center, Madrid, Spain., Gómez-Ramírez J; Instituto de Investigación Biomédica de Cádiz (INIBICA), Department of Psychology, Universidad de Cádiz, Cádiz, Spain., Fernández-Blázquez MA; Department of Experimental Psychology, Complutense University of Madrid (UCM), Madrid, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Jun; Vol. 18 (6), pp. 1177-1185. Date of Electronic Publication: 2021 Sep 05. |
| DOI: | 10.1002/alz.12448 |
| Abstrakt: | Introduction: The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon. Methods: A total of 985 Spanish community-dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi-state Markov models were performed to characterize transitions between states through the dementia continuum. Results: The rate of reversion from MCI to NC was 11%. There were significant non-modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion. Discussion: Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC. (© 2021 the Alzheimer's Association.) |
| Databáze: | MEDLINE |
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