The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations.

Autor:	Karhunen V; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Bond TA; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Zuber V; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Hurtig T; Research Unit of Clinical Neuroscience, Psychiatry, University of Oulu, Oulu, Finland.; PEDEGO Research Unit, Child Psychiatry, University of Oulu, Oulu, Finland.; Clinic of Child Psychiatry, Oulu University Hospital, Oulu, Finland., Moilanen I; PEDEGO Research Unit, Child Psychiatry, University of Oulu, Oulu, Finland.; Clinic of Child Psychiatry, Oulu University Hospital, Oulu, Finland., Järvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University, London, UK., Evangelou M; Department of Mathematics, Imperial College London, London, UK., Rodriguez A; Department of Epidemiology and Biostatistics, Imperial College London, London, UK. a.rodriguez@imperial.ac.uk.; Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary University London, London, UK. a.rodriguez@imperial.ac.uk.
Jazyk:	angličtina
Zdroj:	Translational psychiatry [Transl Psychiatry] 2021 Sep 04; Vol. 11 (1), pp. 455. Date of Electronic Publication: 2021 Sep 04.
DOI:	10.1038/s41398-021-01584-4
Abstrakt:	Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of the prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins. (© 2021. The Author(s).)
Databáze:	MEDLINE
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