Mitochondrial respiration is controlled by Allostery, Subunit Composition and Phosphorylation Sites of Cytochrome c Oxidase: A trailblazer's tale - Bernhard Kadenbach.

Autor: Vogt S; Department of Heart Surgery, Campus Marburg, University Hospital of Giessen and Marburg, D-35043 Marburg, Germany; Cardiovascular Research Laboratory, Biochemical-Pharmacological Center, Philipps-University Marburg, Karl-von-Frisch-Strasse 1, D-35043 Marburg, Germany. Electronic address: vogts@med.uni-marburg.de., Ramzan R; Department of Heart Surgery, Campus Marburg, University Hospital of Giessen and Marburg, D-35043 Marburg, Germany; Cardiovascular Research Laboratory, Biochemical-Pharmacological Center, Philipps-University Marburg, Karl-von-Frisch-Strasse 1, D-35043 Marburg, Germany., Grossman LI; Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA., Singh KK; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Ferguson-Miller S; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States., Yoshikawa S; Picobiology Institute, Graduate School of Life Science, University of Hyogo, 3-2-1 Koto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan., Lee I; College of Medicine, Dankook University, Cheonan-si, Chungcheongnam-do 31116, South Korea., Hüttemann M; Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA. Electronic address: mhuttema@med.wayne.edu.
Jazyk: angličtina
Zdroj: Mitochondrion [Mitochondrion] 2021 Sep; Vol. 60, pp. 228-233. Date of Electronic Publication: 2021 Sep 02.
DOI: 10.1016/j.mito.2021.08.015
Abstrakt: In memoriam of Bernhard Kadenbach: Although the main focus of his research was the structure, function, and regulation of mitochondrial cytochrome c oxidase (CytOx), he earlier studied the mitochondrial phosphate carrier and found an essential role of cardiolipin. Later, he discovered tissue-specific and developmental-specific protein isoforms of CytOx. Defective activity of CytOx is found with increasing age in human muscle and neuronal cells resulting in mitochondrial diseases. Kadenbach proposed a theory on the cause of oxidative stress, aging, and associated diseases stating that allosteric feedback inhibition of CytOx at high mitochondrial ATP/ADP ratios is essential for healthy living while stress-induced reversible dephosphorylation of CytOx results in the formation of excessive reactive oxygen species that trigger degenerative diseases. This article summarizes the main discoveries of Kadenbach related to mammalian CytOx and discusses their implications for human disease.
(Copyright © 2021 Elsevier B.V. and Mitochondria Research Society. All rights reserved.)
Databáze: MEDLINE
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