Whole-Genome Duplications and the Diversification of the Globin-X Genes of Vertebrates.

Autor:	Hoffmann FG; Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Starkville, MS, USA.; Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Starkville, MS, USA., Storz JF; School of Biological Sciences, University of Nebraska, Lincoln, NE, USA., Kuraku S; Molecular Life History Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Japan.; Department of Genetics, Sokendai (Graduate University for Advanced Studies), Mishima, Japan.; Laboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan., Vandewege MW; Department of Biology, Eastern New Mexico University, Portales, NM, USA., Opazo JC; Integrative Biology Group, Universidad Austral de Chile, Valdivia, Chile.; Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.; Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Valdivia, Chile.
Jazyk:	angličtina
Zdroj:	Genome biology and evolution [Genome Biol Evol] 2021 Oct 01; Vol. 13 (10).
DOI:	10.1093/gbe/evab205
Abstrakt:	Globin-X (GbX) is an enigmatic member of the vertebrate globin gene family with a wide phyletic distribution that spans protostomes and deuterostomes. Unlike canonical globins such as hemoglobins and myoglobins, functional data suggest that GbX does not have a primary respiratory function. Instead, evidence suggests that the monomeric, membrane-bound GbX may play a role in cellular signaling or protection against the oxidation of membrane lipids. Recently released genomes from key vertebrates provide an excellent opportunity to address questions about the early stages of the evolution of GbX in vertebrates. We integrate bioinformatics, synteny, and phylogenetic analyses to characterize the diversity of GbX genes in nonteleost ray-finned fishes, resolve relationships between the GbX genes of cartilaginous fish and bony vertebrates, and demonstrate that the GbX genes of cyclostomes and gnathostomes derive from independent duplications. Our study highlights the role that whole-genome duplications (WGDs) have played in expanding the repertoire of genes in vertebrate genomes. Our results indicate that GbX paralogs have a remarkably high rate of retention following WGDs relative to other globin genes and provide an evolutionary framework for interpreting results of experiments that examine functional properties of GbX and patterns of tissue-specific expression. By identifying GbX paralogs that are products of different WGDs, our results can guide the design of experimental work to explore whether gene duplicates that originate via WGDs have evolved novel functional properties or expression profiles relative to singleton or tandemly duplicated copies of GbX. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu