Signalling pathways and transcriptional regulators orchestrating liver development and cancer.

Autor:	Campbell SA; Terry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada., Stephan TL; Terry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada.; Program in Cell and Developmental Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Lotto J; Terry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada.; Program in Cell and Developmental Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Cullum R; Terry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada., Drissler S; Terry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada.; Program in Cell and Developmental Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Hoodless PA; Terry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada.; Program in Cell and Developmental Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Jazyk:	angličtina
Zdroj:	Development (Cambridge, England) [Development] 2021 Sep 01; Vol. 148 (17). Date of Electronic Publication: 2021 Sep 03.
DOI:	10.1242/dev.199814
Abstrakt:	Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell maturity can be perturbed by genetic and environmental factors that disrupt hepatic identity and function. Developmental signals and fetal genetic programmes are often dysregulated or reactivated, leading to dedifferentiation and disease. Here, we highlight signalling pathways and transcriptional regulators that drive liver cell development and primary liver cancers. We also discuss emerging models derived from pluripotent stem cells, 3D organoids and bioengineering for improved studies of signalling pathways in liver cancer and regenerative medicine. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2021. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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