Effects of vatinoxan on xylazine-induced pulmonary alterations in sheep.

Autor: Adam M; Department of Equine and Small Animal Medicine, Faculty of veterinary Medicine, University of Helsinki, Helsinki, Finland.; Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt., Lindén J; Department of Veterinary Bioscience, Faculty of veterinary Medicine, University of Helsinki, Helsinki, Finland.; Finnish Centre for Laboratory Animal Pathology, HiLIFE, University of Helsinki, Helsinki, Finland., Raekallio M; Department of Equine and Small Animal Medicine, Faculty of veterinary Medicine, University of Helsinki, Helsinki, Finland., Meller A; Laboratory Animal Centre, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Mannerström B; Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Abu-Shahba A; Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tanta University, Tanta, Egypt., Seppänen-Kaijansinkko R; Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Salla K; Department of Equine and Small Animal Medicine, Faculty of veterinary Medicine, University of Helsinki, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2022 Jan; Vol. 45 (1), pp. 117-125. Date of Electronic Publication: 2021 Sep 03.
DOI: 10.1111/jvp.13013
Abstrakt: It was hypothesized that premedication with vatinoxan, a peripheral α 2 -adrenoceptor antagonist, would mitigate xylazine-induced pulmonary alterations in sheep. Fourteen adult sheep were allotted into two equal groups and premedicated with either vatinoxan (750 µg/kg IV) or saline and sedated 10 min later with xylazine (500 µg/kg IV). Arterial oxygen saturation (SpO 2 ) was measured and respiratory rate (RR) counted at intervals. The sheep were euthanized with IV pentobarbital 10 min after xylazine administration. The severity of pulmonary parenchymal alterations was assessed and graded grossly and histologically and correlations of the morphological changes with SpO 2 evaluated. Following xylazine injection, SpO 2 was significantly higher and RR significantly lower with vatinoxan than with saline and the sheep administered vatinoxan exhibited significantly smaller quantities of tracheal foam than those receiving saline. No significant differences in macroscopic oedema scores were detected between treatments. In contrast, the vatinoxan-treated animals exhibited significantly graver microscopic interstitial alveolar oedema and haemorrhage than saline-treated animals. The histological severity scores did not correlate with changes in SpO 2 . In conclusion, xylazine induced a marked reduction in SpO 2 which was abolished by the prior administration of vatinoxan. The histologically detected alterations after pentobarbital euthanasia with vatinoxan premedication need to be studied further.
(© 2021 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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