Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments.

Autor:	Ferri C; Rheumatology Unit, University of Modena and Reggio Emilia, School of Medicine, Modena, Italy., Giuggioli D; Rheumatology Unit, University of Modena and Reggio Emilia, School of Medicine, Modena, Italy., Raimondo V; Rheumatology Clinic 'Madonna dello Scoglio' Cotronei, Crotone, Italy., L'Andolina M; Rheumatology Outpatient Clinic, ASP- Vibo Valentia-Tropea Hospital, Tropea, Italy., Dagna L; Ospedale S. Raffaele, Milano, Italy., Tavoni A; Clinical Immunology, University of Pisa, Pisa, Italy., Caso F; Rheumatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy., Ursini F; Medicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Ruscitti P; Rheumatology Unit, Department of Biotechnological & Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Caminiti M; UOD Reumatologia-Grande Ospedale Metropolitano, Reggio Calabria, Italy., Foti R; AOU Policlinico Vittorio Emanuele, Catania, Italy., Riccieri V; Rheumatology, Sapienza-University of Rome, Roma, Italy., Guiducci S; Rheumatology, University of Florence, Firenze, Italy., Pellegrini R; U.O.C. Medicina Interna 'M.Valentini' P.O. Annunziata, Cosenza, Italy., Zanatta E; Rheumatology, University of Padova, Padova, Italy., Varcasia G; U.O.S. Reumatologia, Ospedale Castrovillari, Cosenza, Italy., Olivo D; Rheumatology Outpatient Clinic, San Giovanni di Dio Hospital, Crotone, Italy., Gigliotti P; U.O.T. Specialistica Ambulatoriale ASP 201, Cosenza, Italy., Cuomo G; University of Campania, Luigi Vanvitelli, Napoli, Italy., Murdaca G; Ospedale Policlinico S. Martino-University of Genova, Genova, Italy., Cecchetti R; Ospedale di Portoferraio, Livorno, Italy., De Angelis R; Rheumatology Clinic, Department of Clinical & Molecular Sciences, Marche Polytechnic University, Ancona, Italy., Romeo N; ASO S. Croce e Carle, Cuneo, Italy., Ingegnoli F; Rheumatology, University of Milano, Milano, Italy., Cozzi F; Ospedale 'Villa Salus', Mestre, Italy., Codullo V; Rheumatology, Policlinico San Matteo, Pavia, Italy., Cavazzana I; Rheumatology, Spedali Civili di Brescia, Brescia, Italy., Colaci M; Rheumatology, University of Catania, Catania, Italy., Abignano G; AOR San Carlo di Potenza, Potenza, Italy., De Santis M; Humanitas Clinical and Research Center IRCCS, Milano, Italy., Lubrano E; Rheumatology, Università del Molise, Campobasso, Italy., Fusaro E; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Torino, Italy., Rossa AD; Rheumatology, University of Pisa, Pisa, Italy., Spinella A; Rheumatology Unit, University of Modena and Reggio Emilia, School of Medicine, Modena, Italy., Lumetti F; Rheumatology Unit, University of Modena and Reggio Emilia, School of Medicine, Modena, Italy., De Luca G; Ospedale S. Raffaele, Milano, Italy., Bellando-Randone S; Rheumatology, University of Florence, Firenze, Italy., Visalli E; AOU Policlinico Vittorio Emanuele, Catania, Italy., Dal Bosco Y; AOU Policlinico Vittorio Emanuele, Catania, Italy., Amato G; AOU Policlinico Vittorio Emanuele, Catania, Italy., Giannini D; Clinical Immunology, University of Pisa, Pisa, Italy., Bilia S; Clinical Immunology, University of Pisa, Pisa, Italy., Masini F; University of Campania, Luigi Vanvitelli, Napoli, Italy., Pellegrino G; Rheumatology, Sapienza-University of Rome, Roma, Italy., Pigatto E; Ospedale 'Villa Salus', Mestre, Italy., Generali E; Humanitas Clinical and Research Center IRCCS, Milano, Italy., Mariano GP; UOD Reumatologia-Grande Ospedale Metropolitano, Reggio Calabria, Italy., Pettiti G; ASO S. Croce e Carle, Cuneo, Italy., Zanframundo G; Rheumatology, Policlinico San Matteo, Pavia, Italy., Brittelli R; Rheumatology Clinic 'Madonna dello Scoglio' Cotronei, Crotone, Italy., Aiello V; Rheumatology Clinic 'Madonna dello Scoglio' Cotronei, Crotone, Italy., Caminiti R; Rheumatology Clinic 'Madonna dello Scoglio' Cotronei, Crotone, Italy., Scorpiniti D; Rheumatology Clinic 'Madonna dello Scoglio' Cotronei, Crotone, Italy., Ferrari T; U.O.S. Reumatologia, Ospedale Castrovillari, Cosenza, Italy., Campochiaro C; Ospedale S. Raffaele, Milano, Italy., Brusi V; Medicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Fredi M; Rheumatology, Spedali Civili di Brescia, Brescia, Italy; 27 Rheumatology, University of Catania, Catania, Italy., Moschetti L; Rheumatology, Spedali Civili di Brescia, Brescia, Italy., Cacciapaglia F; UO Reumatologia - DETO, Università di Bari, Bari, Italy., Gragnani L; University of Florence, Firenze, Italy., Monti M; University of Florence, Firenze, Italy., Lorini S; University of Florence, Firenze, Italy., Paparo SR; Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Pisa, Italy., Ragusa F; Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Pisa, Italy., Mazzi V; Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, School of Medicine, Pisa, Italy., Elia G; Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, School of Medicine, Pisa, Italy., Ferrari SM; Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Pisa, Italy., Di Cola I; Rheumatology Unit, Department of Biotechnological & Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Vadacca M; Unità Operativa di Immunoreumatologia - Area Medicina Clinica Policlinico Universitario Campus Bio-Medico di Roma, Roma, Italy., Lorusso S; Unità Operativa di Immunoreumatologia - Area Medicina Clinica Policlinico Universitario Campus Bio-Medico di Roma, Roma, Italy., Barsotti S; Rheumatology, University of Pisa, Pisa, Italy., Aprile ML; Rheumatology, University of Catania, Catania, Italy., Marco T; Rheumatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy., Miccoli M; Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Pisa, Italy., Bosello S; Institute of Rheumatology, Università Cattolica del Sacro Cuore, Rome, and Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy., Matucci-Cerinic M; Rheumatology, University of Florence, Firenze, Italy., D'Angelo S; AOR San Carlo di Potenza, Potenza, Italy., Doria A; Rheumatology, University of Padova, Padova, Italy., Franceschini F; Rheumatology, Spedali Civili di Brescia, Brescia, Italy., Meliconi R; Medicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Iannone F; UO Reumatologia - DETO, Università di Bari, Bari, Italy., Giacomelli R; Unità Operativa di Immunoreumatologia - Area Medicina Clinica Policlinico Universitario Campus Bio-Medico di Roma, Roma, Italy., Zignego AL; Department of Clinical Experimental Medicine, Interdepartmental Hepatology Center MASVE, University of Florence, Firenze, Italy., Fallahi P; Department of Translational Research & New Technologies in Medicine and Surgery, University of Pisa, School of Medicine, Pisa, Italy., Antonelli A; Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, School of Medicine, Pisa, Italy.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2021; Vol. 27 (41), pp. 4245-4252.
DOI:	10.2174/1381612827666210903103935
Abstrakt:	Background: The Covid-19 pandemic may have a deleterious impact on patients with autoimmune systemic diseases (ASD) due to their deep immune-system alterations. Objective: This study aims to investigate the prevalence of symptomatic Covid-19 and its correlations with both organ involvement and ongoing treatments in a large series of Italian ASD patients during the first wave of pandemic. Methods: Our multicenter telephone 6-week survey included 3,029 unselected ASD patients enrolled at 36 tertiary referral centers of northern, central, and southern Italian macro-areas with different diffusion of the pandemic. Symptomatic SARS-CoV-2 infection was classified as definite Covid-19 (presence of symptoms plus positive oral/nasopharyngeal swabs) or highly suspected Covid-19 (highly suggestive symptoms, in the absence of a swab testing). Results: A significantly higher prevalence of definite plus highly suspected Covid-19 compared to the Italian general population was detected in the whole ASD series (p=.000), as well as in patients from the three macro-areas (p=.000 in all). Statistically higher prevalence of Covid-19 was also found in connective tissue diseases compared to chronic arthritis subgroup (p=.000) and in ASD patients with pre-existing interstitial lung involvement (p=.000). Patients treated with either conventional disease-modifying anti-rheumatic drugs (DMARDs) and/or biological DMARDs showed a significantly lower prevalence of Covid-19 (p=.000 in both). Finally, scleroderma patients undergoing low-dose aspirin showed a significantly lower rate of Covid-19 compared to those without (p=0.003). Conclusion: The higher prevalence of Covid-19 in ASD patients, along with the significant correlations with important clinical features and therapeutic regimens, suggests the need to develop targeted prevention/management strategies during the current pandemic wave. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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