Possibility analysis of thyroid imaging parameters for dose adjustment in 131I treatment of hyperthyroidism.

Autor: Zhang X; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Li J; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Zhou H; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Lu Q; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wei H; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Li A; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wei X; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wei Z; Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China - weizhixiao196493@126.com.
Jazyk: angličtina
Zdroj: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.. [Q J Nucl Med Mol Imaging] 2023 Jun; Vol. 67 (2), pp. 152-157. Date of Electronic Publication: 2021 Sep 03.
DOI: 10.23736/S1824-4785.21.03357-4
Abstrakt: Background: To determine the thyroid uptake rate by correcting the background and analyze its clinical significance.
Methods: The study included 161 patients with hyperthyroidism. The thyroid uptake rate was calculated by drawing a 100 pixels ROI (region of interest) background, above and below the thyroid and correcting the thyroid ROI for background counting. At the same time, the clinical baseline characteristic parameters such as age and thyroid volume etc. of patients with hyperthyroidism were collected. The consistency of 99m TcO4uptake rate before treatment and 131 I-uptake rate after treatment, and the correlation between uptake rate of thyroid and baseline characteristic parameters were also analyzed.
Results: The uptake rate of 99m TcO4 was found positively correlated with 3 h-radioactive iodine uptake (RAIU), 24 h-RAIU, 3 h/24 h conversion rate, thyroid volume, 131 I activity free triiodothyronine (FT3) and free thyroxine (FT4), and showed negative correlation with age, effective half-life (P<0.05). The uptake rate of 131 I was found positively correlated with 3 h-RAIU, 24 h-RAIU, 3 h/24 h conversion rate, thyroid volume, 131 I activity, FT3, FT4 (P<0.05). In patients with positive thyrotrophin receptor antibody (TRAb), a significant positive correlation between uptake rate of 99m TcO4 and 131 I (P<0.05) was observed. There was a high consistency between pretreatment uptake rate of 99m TcO4 and post-treatment uptake rate of 131 I (P=0.009; W=0.7).
Conclusions: The corrected thyroid uptake rate is remarkably correlated with clinical characteristic parameters of patients, which can be used to comprehensively evaluate the comprehensive condition of patients with hyperthyroidism.
Databáze: MEDLINE
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