Detection of cutaneous oxygen saturation using a novel snapshot hyperspectral camera: a feasibility study.

Autor: van Manen L; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Birkhoff WAJ; Centre for Human Drug Research, Leiden, The Netherlands., Eggermont J; Leiden University Medical Center, Division of Image Processing, Department of Radiology, Leiden, The Netherlands., Hoveling RJM; Quest Medical Imaging BV, Middenmeer, The Netherlands., Nicklin P; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Burggraaf J; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.; Centre for Human Drug Research, Leiden, The Netherlands., Wilson R; Department of Anesthesiology, Critical Care Medicine, and Surgery, Memorial Sloan Kettering Cancer Center Research, New York, NY, USA., Mieog JSD; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Robinson DJ; Erasmus Medical Center, Center for Optical Diagnostics and Therapy, Department of Otorhinolaryngology and Head and Neck Surgery, Rotterdam, The Netherlands., Vahrmeijer AL; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Bradbury MS; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; MSK-Cornell Center for Translation of Cancer Nanomedicines, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Molecular Pharmacology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA., Dijkstra J; Leiden University Medical Center, Division of Image Processing, Department of Radiology, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Quantitative imaging in medicine and surgery [Quant Imaging Med Surg] 2021 Sep; Vol. 11 (9), pp. 3966-3977.
DOI: 10.21037/qims-21-46
Abstrakt: Background: Tissue necrosis, a consequence of inadequate tissue oxygenation, is a common post-operative complication. As current surgical assessments are often limited to visual and tactile feedback, additional techniques that can aid in the interrogation of tissue viability are needed to improve patient outcomes. In this bi-institutional pilot study, the performance of a novel snapshot hyperspectral imaging camera to detect superficial cutaneous oxygen saturation (StO 2 ) was evaluated.
Methods: Healthy human volunteers were recruited at two participating centers. Cutaneous StO 2 of the forearm was determined by a snapshot hyperspectral camera on two separate study days during occlusion-reperfusion of the brachial artery and after induction of local vasodilation. To calculate the blood StO 2 at each pixel in the multispectral image, spectra were selected, and fitting was performed over wavelengths ranging from 470 to 950 nm.
Results: Quantitative detection of physiological changes in cutaneous StO 2 levels was feasible in all sixteen volunteers. A significant (P<0.001) decrease in cutaneous StO 2 levels from 78.3% (SD: 15.3) at baseline to 60.6% (SD: 19.8) at the end of occlusion phase was observed, although StO 2 levels returned to baseline after five minutes. Mean cutaneous StO 2 values were similar in the same subjects on separate study days (Pearson R2: 0.92 and 0.77, respectively) at both centers. Local vasodilation did not yield significant changes in cutaneous StO 2 values.
Conclusions: This pilot study demonstrated the feasibility of a snapshot hyperspectral camera for detecting quantitative physiological changes in cutaneous StO 2 in normal human volunteers, and serves as a precursor for further validation in perioperative studies.
Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/qims-21-46). RJH is an employee/paid consultant for Quest Medical Imaging. The other authors have no conflicts of interest to declare.
(2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.)
Databáze: MEDLINE
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