Medial entorhinal cortex lesions produce delay-dependent disruptions in memory for elapsed time.

Autor: Vo A; Department of Psychological Sciences, University of San Diego, San Diego, CA 92110, USA., Tabrizi NS; Department of Psychological Sciences, University of San Diego, San Diego, CA 92110, USA., Hunt T; Department of Psychological Sciences, University of San Diego, San Diego, CA 92110, USA., Cayanan K; Department of Psychological Sciences, University of San Diego, San Diego, CA 92110, USA., Chitale S; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, USA., Anderson LG; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, USA., Tenney S; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, USA., White AO; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, USA; Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, USA., Sabariego M; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, USA. Electronic address: msabarie@mtholyoke.edu., Hales JB; Department of Psychological Sciences, University of San Diego, San Diego, CA 92110, USA. Electronic address: jhales@sandiego.edu.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2021 Nov; Vol. 185, pp. 107507. Date of Electronic Publication: 2021 Aug 30.
DOI: 10.1016/j.nlm.2021.107507
Abstrakt: Our memory for time is a fundamental ability that we use to judge the duration of events, put our experiences into a temporal context, and decide when to initiate actions. The medial entorhinal cortex (MEC), with its direct projections to the hippocampus, has been proposed to be the key source of temporal information for hippocampal time cells. However, the behavioral relevance of such temporal firing patterns remains unclear, as most of the paradigms used for the study of temporal processing and time cells are either spatial tasks or tasks for which MEC function is not required. In this study, we asked whether the MEC is necessary for rats to perform a time duration discrimination task (TDD), in which rats were trained to discriminate between 10-s and 20-s delay intervals. After reaching a 90% performance criterion, the rats were assigned to receive an excitotoxic MEC-lesion or sham-lesion surgery. We found that after recovering from surgery, rats with MEC lesions were impaired on the TDD task in comparison to rats with sham lesions, failing to return to criterion performance. Their impairment, however, was specific to the longer, 20-s delay trials. These results indicate that time processing is dependent on MEC neural computations only for delays that exceed 10 s, perhaps because long-term memory resources are needed to keep track of longer time intervals.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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