Rats use memory confidence to guide decisions.

Autor:	Joo HR; Medical Scientist Training Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA; Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA. Electronic address: hannah.joo@ucsf.edu., Liang H; Neuroscience Graduate Program, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA., Chung JE; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA; Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA., Geaghan-Breiner C; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA; Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA., Fan JL; Bioengineering Graduate Program, University of California, Berkeley/University of California, San Francisco, 1675 Owens Street, San Francisco, CA 94158, USA., Nachman BP; Physics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA; Berkeley Institute of Data Science, University of California, Berkeley, 190 Doe Library, Berkeley, CA 94720, USA., Kepecs A; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA., Frank LM; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA; Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA. Electronic address: loren@phy.ucsf.edu.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2021 Oct 25; Vol. 31 (20), pp. 4571-4583.e4. Date of Electronic Publication: 2021 Sep 01.
DOI:	10.1016/j.cub.2021.08.013
Abstrakt:	Memory enables access to past experiences to guide future behavior. Humans can determine which memories to trust (high confidence) and which to doubt (low confidence). How memory retrieval, memory confidence, and memory-guided decisions are related, however, is not understood. In particular, how confidence in memories is used in decision making is unknown. We developed a spatial memory task in which rats were incentivized to gamble their time: betting more following a correct choice yielded greater reward. Rat behavior reflected memory confidence, with higher temporal bets following correct choices. We applied machine learning to identify a memory decision variable and built a generative model of memories evolving over time that accurately predicted both choices and confidence reports. Our results reveal in rats an ability thought to exist exclusively in primates and introduce a unified model of memory dynamics, retrieval, choice, and confidence. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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