[Predictors of biochemical recurrence after radical prostatectomy at an oncology reference center in Colombia.]

Autor:	Molina-Barrera ÁM; Departamento de Urología. Universidad de Antioquia. Facultad de Medicina. Medellín. Colombia., Ramos-Ulloa JG; Fellow Urología Oncológica. Instituto Nacional de Cancerología. Bogotá. Colombia., Becerra-Méndez LM; Fellow Urología Oncológica. Instituto Nacional de Cancerología. Bogotá. Colombia., García-Valencia J; Magister y PhD en Epidemiología. Universidad de Antioquia. Colombia., Varela-Ramírez R; Urólogo Oncólogo. Instituto Nacional de Cancerología. Bogotá. Colombia., Silva-Chacón D; Universidad de Antioquia. Facultad de Medicina. Medellín. Colombia.
Jazyk:	Spanish; Castilian
Zdroj:	Archivos espanoles de urologia [Arch Esp Urol] 2021 Sep; Vol. 74 (7), pp. 656-663.
Abstrakt:	Objective: To determine predictors of BCR in patients with localized PCa undergoing RP at an oncology reference center in Colombia. Materials and Methods: A retrospective analytical study was conducted on patients with localized PCa undergoing RP and who at least had one adverse pathological factor for BCR. We consider BCR as two consecutive elevations of PSA after RP, greater than 0.2 ng/ml. For the bivariate analysis we used Kaplan-Meier, and Cox proportional risk analysis to estimate the hazard ratio as well as to determine variables independently associated with the outcome. Results: 280 patients were included. The medianage was 65.3 years, with a median follow up of 52.2 months. BCR occurred in 39% of patients, with a median BCR time of 24.8 months. In the multivariate analysis, high risk [HR 2.07 (95% CI 1.11 - 3.86)], positive surgical margins [HR 2.79 (95% CI 1.66 - 4.69)] and tertiary Gleason pattern [HR 2.16 (95% CI 1.16 - 4.01)] were identified as independent variables associated significantly with BCR. Limitations include retrospective design and sample size. Conclusions: High risk, positive surgical margins and the presence of tertiary Gleason pattern are the predictive factors of BCR after RP in the Colombian population.
Databáze:	MEDLINE
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