2D and 3D numerical models to evaluate trabecular bone damage.

Autor: Buccino F; Department of Mechanical Engineering, Politecnico Di Milano, Via La Masa 1, 20156, Milan, Italy., Colombo C; Department of Mechanical Engineering, Politecnico Di Milano, Via La Masa 1, 20156, Milan, Italy., Duarte DHL; Department of Mechanical Engineering, Politecnico Di Milano, Via La Masa 1, 20156, Milan, Italy.; Berlin, Germany., Rinaudo L; TECHNOLOGIC S.R.L. Hologic Italia, Lungo Dora Voghera, 34/36A, 10153, Turin, Italy., Ulivieri FM; Nuclear Medicine-Bone Metabolic Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, via Francesco Sforza 75, 20122, Milan, Italy., Vergani LM; Department of Mechanical Engineering, Politecnico Di Milano, Via La Masa 1, 20156, Milan, Italy. laura.vergani@polimi.it.
Jazyk: angličtina
Zdroj: Medical & biological engineering & computing [Med Biol Eng Comput] 2021 Oct; Vol. 59 (10), pp. 2139-2152. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1007/s11517-021-02422-x
Abstrakt: The comprehension of trabecular bone damage processes could be a crucial hint for understanding how bone damage starts and propagates. Currently, different approaches to bone damage identification could be followed. Clinical approaches start from dual X-ray absorptiometry (DXA) technique that can evaluate bone mineral density (BMD), an indirect indicator of fracture risk. DXA is, in fact, a two-dimensional technology, and BMD alone is not able to predict the effective risk of fractures. First attempts in overcoming this issue have been performed with finite element (FE) methods, combined with the use of three-dimensional high-resolution micro-computed tomographic images. The purpose of this work is to evaluate damage initiation and propagation in trabecular vertebral porcine samples using 2D linear-elastic FE models from DXA images and 3D linear FE models from micro-CT images. Results show that computed values of strains with 2D and 3D approaches (e.g., the minimum principal strain) are of the same order of magnitude. 2D DXA-based models still remain a powerful tool for a preliminary screening of trabecular regions that are prone to fracture, while from 3D micro-CT-based models, it is possible to reach details that permit the localization of the most strained trabecula.
(© 2021. The Author(s).)
Databáze: MEDLINE
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