Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial.

Autor: Marcadenti A; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil. amarcaden@hcor.com.br.; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil. amarcaden@hcor.com.br., Weber B; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Bersch-Ferreira AC; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Machado RHV; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Torreglosa CR; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., de Sousa Lara EM; Health Knowledge Implementation Laboratory (LICS), Hospital do Coração (HCor), São Paulo, São Paulo, Brazil., da Silva LR; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Santos RHN; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Miyada DHK; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Sady ERR; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Costa RP; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil., Piegas L; Division of Cardiology, Hospital do Coração (HCor), São Paulo, São Paulo, Brazil., de Abreu-Silva EO; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil.; Division of Cardiology, Hospital do Coração (HCor), São Paulo, São Paulo, Brazil.; Hemodynamics Service, Hospital do Servidor Público Estadual (HSPE), São Paulo, São Paulo, Brazil., de Quadros AS; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil., Weschenfelder C; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil., Dos Santos JL; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil., Souza GC; Division of Nutrition, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.; Post-Graduation Program in Food, Nutrition and Health, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Parahiba SM; Post-Graduation Program in Food, Nutrition and Health, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil., Fayh APT; Department of Nutrition, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil., Bezerra DS; Faculty of Health Science of Trairi, Universidade Federal do Rio Grande do Norte (FACISA-UFRN), Santa Cruz, Rio Grande do Norte, Brazil., Carvalho APPF; Clinical Nutrition Unit, Hospital de Clínicas, Universidade Federal de Goiás (HC-UFG/EBSERH), Goiânia, Goiás, Brazil., Machado MMA; Clinical Nutrition Unit, Hospital de Clínicas, Universidade Federal de Goiás (HC-UFG/EBSERH), Goiânia, Goiás, Brazil., Vasconcelos SML; Faculty of Nutrition, Universidade Federal de Alagoas (UFAL), Maceió, Alagoas, Brazil., Araújo J; Faculty of Nutrition, Universidade Federal de Alagoas (UFAL), Maceió, Alagoas, Brazil., de Figueiredo Neto JA; Department of Cardiology, Universidade Federal do Maranhão (UFMA), São Luiz, Maranhão, Brazil., Dias LPP; Department of Cardiology, Universidade Federal do Maranhão (UFMA), São Luiz, Maranhão, Brazil., Nagano FEZ; Complexo Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR), Curitiba, Paraná, Brazil., de Almeida CCP; Universidade Federal do Paraná (UFPR), Curitiba, Paraná, Brazil., Moreira ASB; Instituto Nacional de Cardiologia (INC), Rio de Janeiro, Rio de Janeiro, Brazil., Gapanowicz DP; Instituto Nacional de Cardiologia (INC), Rio de Janeiro, Rio de Janeiro, Brazil., Purgatto E; Department of Food Science and Experimental Nutrition/Food Research Center, Faculty of Pharmaceutical Sciences, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil., Rogero MM; Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil., Sampaio GR; Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil., da Silva Torres EAF; Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil., Duarte GBS; Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Science, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil., Cavalcanti AB; HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, São Paulo, SP, Zip Code 04004-050, Brazil.
Jazyk: angličtina
Zdroj: Trials [Trials] 2021 Sep 01; Vol. 22 (1), pp. 582. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1186/s13063-021-05494-0
Abstrakt: Background: Nut consumption has been related to improvements on cardiometabolic parameters and reduction in the severity of atherosclerosis mainly in primary cardiovascular prevention. The objective of this trial is to evaluate the effects of the Brazilian Cardioprotective Diet (DIeta CArdioprotetora Brasileira, DICA Br) based on consumption of inexpensive locally accessible foods supplemented or not with mixed nuts on cardiometabolic features in patients with previous myocardial infarction (MI).
Methods: DICA-NUTS study is a national, multicenter, randomized 16-week follow-up clinical trial. Patients over 40 years old with diagnosis of previous MI in the last 2 to 6 months will be recruited (n = 388). A standardized questionnaire will be applied to data collection and blood samples will be obtained. Patients will be allocated in two groups: Group 1: DICA Br supplemented with 30 g/day of mixed nuts (10 g of peanuts, 10 g of cashew, 10 g of Brazil nuts); and Group 2: only DICA Br. The primary outcome will consist of LDL cholesterol means (in mg/dL) after 16 weeks of intervention. Secondary outcomes will consist of other markers of lipid profile, glycemic profile, and anthropometric data.
Discussion: It is expected that DICA Br supplemented with mixed nuts have superior beneficial effects on cardiometabolic parameters in patients after a MI, when compared to DICA Br.
Trial Registration: ClinicalTrials.gov Identifier NCT03728127 . First register: November 1, 2018; Last update: June 16, 2021. World Health Organization Universal Trial Number (WHO-UTN): U1111-1259-8105.
(© 2021. The Author(s).)
Databáze: MEDLINE
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