Assessment of thiol/disulfide and ischemia modified albumin level and oxidative stress in pregnancies complicated by meconium.

Autor:	Aglamıs O; Estetik International Quasar Clinic, Istanbul, Turkey., Ergani SY; Etlik Zubeyde Hanim Maternity and Women's Health Teaching And Research Hospital, Ankara, Turkey., Erel O; Faculty of Medicine, Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey., Celen S; Etlik Zubeyde Hanim Maternity and Women's Health Teaching And Research Hospital, Ankara, Turkey., Caglar AT; Etlik Zubeyde Hanim Maternity and Women's Health Teaching And Research Hospital, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 8083-8089. Date of Electronic Publication: 2021 Sep 01.
DOI:	10.1080/14767058.2021.1961726
Abstrakt:	Objective: The purpose of this study is to evaluate antioxidant balance in pregnant women with meconium-stained amniotic fluid. Methods: Forty pregnant women with meconium-stained amniotic fluid and 40 pregnant women with non-meconium-stained amniotic fluid were included in the study. By checking the ischemia modified albumin (IMA) level and thiol/disulfide homeostasis in the maternal blood during labor and in newborn umbilical cord blood at the first minute after birth, antioxidant/oxidant balance was evaluated. Results: No statistically significant difference was found between the maternal albumin levels. Maternal IMA level was statistically significantly higher in the meconium group than in the control group ( p = .045). Maternal native thiol (SH) and maternal total thiol levels were statistically significantly higher in the control group than in the meconium group ( p = .042 and p = .009, respectively). No statistically significant difference was found between maternal disulfide/native thiol ( p = .262), maternal disulfide/total thiol ( p = .152), maternal native thiol/total thiol ( p = .153) rates in both groups. No statistically significant difference was determined between the patients with meconium and the control group in terms of cord blood IMA ( p = .474), Albumin levels ( p = .664), cord blood Native thiol ( p = .944), cord blood total thiol ( p = .612) levels and cord blood disulfide/native thiol ( p = .240), cord blood disulfide/total thiol ( p = .276), cord blood native thiol/total thiol ( p = .277) rates. Conclusion: Determination of a decrease in SH and Total Thiol levels in maternal serum and an increase in the meconium group's IMA level was interpreted as a shift of antioxidant balance toward oxidant in this group.
Databáze:	MEDLINE
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