Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature.

Autor: Pontes FSC; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil., Mosqueda-Taylor A; Health Care Department, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico., de Souza LL; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil.; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., de Paula LP; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil., Batista LAL; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil., Rodrigues-Fernandes CI; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Paiva E Costa AM; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil., de Abreu MC; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil.; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Gomez RS; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Oliveira EM; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Department of Oral Pathology and Oral Biology, School of Dentistry, University of Pretoria, Pretoria, South Africa., Rahimi S; Department of Pathology, Queen Alexandra Hospital, Portsmouth, UK., Brennan PA; Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK., Pontes HAR; Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil.; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2022 Jan; Vol. 51 (1), pp. 5-12. Date of Electronic Publication: 2021 Sep 20.
DOI: 10.1111/jop.13238
Abstrakt: Background: Hybrid odontogenic lesions combine histopathological characteristics of two or more odontogenic cysts and/or tumours. The aim of this study was to evaluate the available data on hybrid odontogenic lesions (HOL) and to analyse their epidemiological/clinical features and biological behaviour.
Methods: An electronic search was done in January 2021 using multiple databases. Eligibility criteria encompassed publications with sufficient clinical and histological information to confirm the tumours' diagnoses.
Results: A total of 147 articles were included in this study, comprising 203 cases. Calcifying odontogenic cyst associated with odontoma (COC/OD) (37/18.2%) was the most common HOL. Females were more affected with a mean age of 24.9 years. Lesions presented as asymptomatic swellings, with a mean evolution time of 8.2 months (0.3-96), and mean tumour size of 4.8 cm (0.3-7). Radiographic aspects frequently showed radiolucent (139/68.4%) and unilocular (52/25.6%) images with well-defined limits (48/23.6%). The lesions mostly affected mandibular pre-molars (69/34%) and mandibular molars (69/34%) regions. Enucleation (89/43.8%) and surgical excision (59/29%) were the most common treatment modalities. The mean follow-up time was 33.8 months (0.5-216 months) and recurrences were observed in four cases (1.9%), all of which were central odontogenic fibroma associated with central giant cell granuloma (COF/CGCG).
Conclusion: COC/OD is the most common HOL and recurrence is a rare event, being usually associated with the diagnosis of COF/CGCG.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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