Disruption of the biological activity of protease-activated receptors2/4 in adults rather than children in SARS CoV-2 virus-mediated mortality in COVID-19 infection.

Autor: Singh Y; Department of Pharmacology, Maharishi Arvind College of Pharmacy, Ambabari, Jaipur, India., Fuloria NK; Department of Pharmacy I Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong, Kedah, Malaysia., Fuloria S; Department of Pharmacy I Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong, Kedah, Malaysia., Subramaniyan V; Department of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, Jenjarom Selangor, Malaysia., Almalki WH; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Gupta G; Department of Pharmacology, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India., Shaikh MAJ; Department of Pharmacology, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India., Singh M; School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India., Al-Abbasi FA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Jazyk: angličtina
Zdroj: Drug development research [Drug Dev Res] 2021 Dec; Vol. 82 (8), pp. 1075-1078. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1002/ddr.21874
Abstrakt: One of the most remarkable results in 2019 is the reduced prevalence and death of children from coronavirus infection (COVID-19). In 2019, a worldwide pandemic impacted around 0.1 billion individuals, with over 3.5 million mortality reported in the literature. There is minimal knowledge on SARS-CoV-2 infection immunological responses in kids. Studies have been focused mostly on adults and children since the course of pediatric sickness is often short. In adults, severe COVID-19 is related to an excessive inflammatory reaction. Macrophages and monocytes are well known to contribute to this systemic response, although numerous lines are indicative of the importance of neutrophils. An increased number of neutrophils and neutrophil to lymphocyte ratios are early signs of SARS-CoV-2 and a worse prognosis. In this study that it is crucial to monitor PAR2 and PAR4 expression and function (since nursing children have elevated levels) and the inhibiting the normal physiology through the use of anticoagulants may exacerbate the problem in adults. Thus, in COVID-19 infection, we propose the use of antiplatelet (thromboxane A2 inhibitors), if required rather than anticoagulants (FXa and thrombin Inhibitors).
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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