Antigen Test Performance Among Children and Adults at a SARS-CoV-2 Community Testing Site.

Autor: Ford L; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Whaley MJ; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Shah MM; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Salvatore PP; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Segaloff HE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Bureau of Communicable Diseases, Wisconsin Department of Health Services, Madison, Wisconsin, USA., Delaney A; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Currie DW; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Boyle-Estheimer L; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., O'Hegarty M; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Morgan CN; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Meece J; Integrated Research and Development Laboratory, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA., Ivacic L; Integrated Research and Development Laboratory, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA., Thornburg NJ; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Tamin A; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Harcourt JL; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Folster JM; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Medrzycki M; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Jain S; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Wong P; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Goffard K; Winnebago County Health Department, Oshkosh, Wisconsin, USA., Gieryn D; Winnebago County Health Department, Oshkosh, Wisconsin, USA., Kahrs J; Student Recreation and Wellness, University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA., Langolf K; Sponsored Programs and Risk and Safety, University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA., Zochert T; Sponsored Programs and Risk and Safety, University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA., Tate JE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Hsu CH; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kirking HL; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2021 Dec 31; Vol. 10 (12), pp. 1052-1061.
DOI: 10.1093/jpids/piab081
Abstrakt: Background: Performance characteristics of SARS-CoV-2 antigen tests among children are limited despite the need for point-of-care testing in school and childcare settings. We describe children seeking SARS-CoV-2 testing at a community site and compare antigen test performance to real-time reverse transcription-polymerase chain reaction (RT-PCR) and viral culture.
Methods: Two anterior nasal specimens were self-collected for BinaxNOW antigen and RT-PCR testing, along with demographics, symptoms, and exposure information from individuals ≥5 years at a community testing site. Viral culture was attempted on residual antigen or RT-PCR-positive specimens. Demographic and clinical characteristics, and the performance of SARS-CoV-2 antigen tests, were compared among children (<18 years) and adults.
Results: About 1 in 10 included specimens were from children (225/2110); 16.4% (37/225) were RT-PCR-positive. Cycle threshold values were similar among RT-PCR-positive specimens from children and adults (22.5 vs 21.3, P = .46) and among specimens from symptomatic and asymptomatic children (22.5 vs 23.2, P = .39). Sensitivity of antigen test compared to RT-PCR was 73.0% (27/37) among specimens from children and 80.8% (240/297) among specimens from adults; among specimens from children, specificity was 100% (188/188), positive and negative predictive values were 100% (27/27) and 94.9% (188/198), respectively. Virus was isolated from 51.4% (19/37) of RT-PCR-positive pediatric specimens; all 19 had positive antigen test results.
Conclusions: With lower sensitivity relative to RT-PCR, antigen tests may not diagnose all positive COVID-19 cases; however, antigen testing identified children with live SARS-CoV-2 virus.
(Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2021.)
Databáze: MEDLINE
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