The relationship between brain structure and general psychopathology in preadolescents.

Autor: Mewton L; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Lees B; The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia., Squeglia LM; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Forbes MK; Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, NSW, Australia., Sunderland M; The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia., Krueger R; University of Minnesota, Minneapolis, MN, USA., Koch FC; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Baillie A; Sydney School of Health Sciences, The University of Sydney, Sydney, NSW, Australia., Slade T; The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia., Hoy N; Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Teesson M; The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia.
Jazyk: angličtina
Zdroj: Journal of child psychology and psychiatry, and allied disciplines [J Child Psychol Psychiatry] 2022 Jul; Vol. 63 (7), pp. 734-744. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1111/jcpp.13513
Abstrakt: Background: An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging.
Methods: This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study ® (n = 11,875; age range = 9-10 years; male = 52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area.
Results: Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents.
Conclusions: The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses.
(© 2021 Association for Child and Adolescent Mental Health.)
Databáze: MEDLINE
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