Molecular analysis of the 2012 Bundibugyo virus disease outbreak.

Autor:	Hulseberg CE; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Kumar R; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Di Paola N; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Larson P; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Nagle ER; National Biodefense Analysis and Countermeasures Center, Frederick, MD 21702, USA., Richardson J; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Hanson J; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Wauquier N; Metabiota, Inc., Kinshasa, Democratic Republic of the Congo., Fair JN; Metabiota, Inc., Kinshasa, Democratic Republic of the Congo., Makuwa M; Metabiota, Inc., Kinshasa, Democratic Republic of the Congo., Mulembakani P; Metabiota, Inc., Kinshasa, Democratic Republic of the Congo., Muyembe-Tamfum JJ; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Schoepp RJ; Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Sanchez-Lockhart M; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Palacios GF; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA., Kugelman JR; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Jazyk:	angličtina
Zdroj:	Cell reports. Medicine [Cell Rep Med] 2021 Jul 27; Vol. 2 (8), pp. 100351. Date of Electronic Publication: 2021 Jul 27 (Print Publication: 2021).
DOI:	10.1016/j.xcrm.2021.100351
Abstrakt:	Bundibugyo virus (BDBV) is one of four ebolaviruses known to cause disease in humans. Bundibugyo virus disease (BVD) outbreaks occurred in 2007-2008 in Bundibugyo District, Uganda, and in 2012 in Isiro, Province Orientale, Democratic Republic of the Congo. The 2012 BVD outbreak resulted in 38 laboratory-confirmed cases of human infection, 13 of whom died. However, only 4 BDBV specimens from the 2012 outbreak have been sequenced. Here, we provide BDBV sequences from seven additional patients. Analysis of the molecular epidemiology and evolutionary dynamics of the 2012 outbreak with these additional isolates challenges the current hypothesis that the outbreak was the result of a single spillover event. In addition, one patient record indicates that BDBV's initial emergence in Isiro occurred 50 days earlier than previously accepted. Collectively, this work demonstrates how retrospective sequencing can be used to elucidate outbreak origins and provide epidemiological contexts to a medically relevant pathogen. Competing Interests: The authors declare no competing interests.
Databáze:	MEDLINE
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