Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats.

Autor:	Khalifeh S; Cognitive and Neuroscience Research Center (CNRC), Amiralmomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Khodamoradi M; Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran., Hajali V; Quchan Higher Health Education Center, Mashhad University of Medical Sciences, Mashhad, Iran., Ghazvini H; Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.; Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Eliasy L; Department of Anatomical Sciences, Golestan University of Medical Sciences, Golestan, Iran., Kheradmand A; Department of Pharmacology and Toxicology, school of pharmacy, International campus, Iran University of medical sciences, Tehran, Iran., Farnia V; Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran., Akhtari J; Immunogenetic Research Center, Mazandaran University of medical science, Sari, Iran., Shahveisi K; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran., Ghalehnoei H; Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Jazyk:	angličtina
Zdroj:	Galen medical journal [Galen Med J] 2019 Apr 15; Vol. 8, pp. e1182. Date of Electronic Publication: 2019 Apr 15 (Print Publication: 2019).
DOI:	10.31661/gmj.v0i0.1182
Abstrakt:	Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/ kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Results: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. (Copyright© 2019, Galen Medical Journal.)
Databáze:	MEDLINE
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