Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study).

Autor: Garg PK; Division of Cardiology, USC Keck School of Medicine, Los Angeles, California. Electronic address: parveeng@med.usc.edu., Norby FL; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, California., Wang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota., Krishnappa D; Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota., Soliman EZ; Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, and Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina., Lutsey PL; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Ballantyne CM; Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, Houston, Texas; The Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, Texas., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia., Chen LY; Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.
Jazyk: angličtina
Zdroj: The American journal of cardiology [Am J Cardiol] 2021 Nov 01; Vol. 158, pp. 45-52. Date of Electronic Publication: 2021 Aug 28.
DOI: 10.1016/j.amjcard.2021.07.043
Abstrakt: We evaluated the association of longitudinal changes in circulating levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) and high sensitivity cardiac troponin T (hs-cTnT) with the burden of arrhythmias as captured by 2-week ambulatory ECG monitoring. This study included 1,930 Atherosclerosis Risk in Communities Study participants who wore a leadless, ambulatory ECG monitor (Zio XT Patch) at visit 6 (2016 to 2017) and had cardiac biomarkers measured at visit 6 and visit 4 (median of 19 years earlier). The mean age of participants at V6 was 79 ± 5 years, 41% were men, and 22% were black. Adjusting for demographics, body mass index, smoking, diabetes, hypertension, stroke, left ventricular mass, cardiac medications, patch wear time, visit 4 levels of NT-proBNP and hs-cTnT, and relative change in hs-cTnT, each log-transformed unit relative increase in NT-proBNP was associated with a higher likelihood of nonsustained ventricular tachycardia (odds ratio 1.29, 95% confidence interval [CI] 1.12 to 1.48), a higher number of daily atrial tachycardia episodes (geometric mean ratio [GMR] 1.16, 95% CI 1.10 to 1.21), and a higher daily ectopic burden (premature ventricular contractions -GMR 1.42, 95% CI 1.25 to 1.62; premature atrial contractions -GMR 1.40, 95% CI 1.25 to 1.57). In fully adjusted analyses, each log-transformed unit relative increase in hs-cTnT was only found to be weakly associated with a higher daily premature ventricular contraction burden (GMR 1.31, 95% CI 1.01 to 1.70). In conclusion, longitudinal change in NT-proBNP was associated with an increased atrial and ventricular arrhythmia burden.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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