Evaluation of using fresh frozen plasma for patients with cirrhosis at a tertiary healthcare center in Turkey: Strict transfusion policies are essential.

Autor: Seyhanli A; Department of Hematology, Sivas Numune Hospital, Sivas, Turkey. Electronic address: ahmet.seyhanli@deu.edu.tr., Ozkan YC; Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. Electronic address: yazgulucansu.ozkan@deu.edu.tr., Bengi G; Department of Gastroenterology and Hepatology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. Electronic address: goksel.bengi@deu.edu.tr., Alacacioglu I; Department of Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. Electronic address: inci.alacacioglu@deu.edu.tr., Ozsan GH; Department of Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. Electronic address: hayri.ozsan@deu.edu.tr., Demirkan F; Department of Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. Electronic address: fatih.demirkan@deu.edu.tr.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2021 Dec; Vol. 60 (6), pp. 103247. Date of Electronic Publication: 2021 Aug 26.
DOI: 10.1016/j.transci.2021.103247
Abstrakt: Aim: Management of blood transfusions is a critical issue, especially in cirrhotic patients, because of the absence of national policies in many countries. Fresh frozen plasma (FFP) is a common blood component misused excessively in various clinical situations and cirrhosis patients without any scientific rationale. We evaluated the FFP transfusions in patients with cirrhosis at our tertiary care hospital.
Material and Method: The cases with cirrhosis diagnosed between 2014 and 2020 were selected using the hospital database. The appropriateness of FFP transfusion was determined based on the Practice Guidance by the American Association for the Study of Liver Diseases and Italian guidelines.
Result: Two hundred and six liver cirrhosis patients were identified who received FFP transfusion. The median age was 63 (22-94). Of the 206 patients, 79 (38.3 %) were female, and 127 (61.7 %) were men. The most common causes of liver cirrhosis were alcohol (27.7 %). 45.6 % of the patients were in Child-Pugh Class C. We found 62.1 % of FFP replacements were inappropriately used. Most inappropriate use of FFP (22.8 %, n = 47) occurred to correct prolonged INR in the absence of bleeding.
Conclusion: To avoid inappropriate usage of FFP, regular utilization reviews and formal education programs can be helpful. Our clinic has planned to arrange educational programs for physicians to use blood products appropriately and minimize transfusion-related side effects.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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