Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?

Autor: Güntekin B; Research Institute for Health Sciences and Technologies (SABITA), Regenerative and Restorative Medicine Research Center (REMER), Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Aktürk T; Research Institute for Health Sciences and Technologies (SABITA), Regenerative and Restorative Medicine Research Center (REMER), Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.; Vocational School, Program of Electroneurophysiology, Istanbul Medipol University, Istanbul, Turkey.; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands., Arakaki X; Huntington Medical Research Institutes, Pasadena, California, USA., Bonanni L; Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy., Del Percio C; Department of Physiology and Pharmacology 'Vittorio Erspamer', Sapienza University of Rome, Rome, Italy., Edelmayer R; Alzheimer's Association, Chicago, Illinois, USA., Farina F; School of Psychology, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Ferri R; Oasi Research Institute - IRCCS, Troina, Italy., Hanoğlu L; Department of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Kumar S; Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Lizio R; IRCCS SDN, Napoli, Italy., Lopez S; Department of Physiology and Pharmacology 'Vittorio Erspamer', Sapienza University of Rome, Rome, Italy., Murphy B; BrainWaveBank Ltd, Dublin, Ireland., Noce G; IRCCS SDN, Napoli, Italy., Randall F; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, USA., Sack AT; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands., Stocchi F; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy., Yener G; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey., Yıldırım E; Research Institute for Health Sciences and Technologies (SABITA), Regenerative and Restorative Medicine Research Center (REMER), Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.; Vocational School, Program of Electroneurophysiology, Istanbul Medipol University, Istanbul, Turkey., Babiloni C; Alzheimer's Association, Chicago, Illinois, USA.; Institute for Research and Medical Care, Hospital San Raffaele of Cassino, Cassino, Italy.
Jazyk: angličtina
Zdroj: Psychophysiology [Psychophysiology] 2022 May; Vol. 59 (5), pp. e13934. Date of Electronic Publication: 2021 Aug 30.
DOI: 10.1111/psyp.13934
Abstrakt: Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer's disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer's Association reviewed the field literature and reached consensus on the event-related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer's, Parkinson's (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4-7 Hz) phase-locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascular cognitive impairment patients. Non-phase-locked alpha (8-12 Hz) and beta (13-30 Hz) oscillations were abnormally reduced (event-related desynchronization, ERD) in AD patients relative to CU. However, studies on patients with other dementias remain lacking. Delta and theta phase-locked EROs during oddball tasks may be useful neurophysiological biomarkers of cognitive systems at work in heuristic and intervention clinical trials performed in AD patients, but more research is needed regarding their potential role for other dementias.
(© 2021 Society for Psychophysiological Research.)
Databáze: MEDLINE
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