Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study.

Autor: Luna J; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.; Department of Neurology, CHU Limoges, Centre de Référence SLA et autres maladies du neurone moteur, Limoges, France., Jost J; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France., Diagana M; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.; Neurology Department, CHU de Nouakchott, Mauritania., Ait Aissa L; Laboratoire de Recherche en Neurosciences Université Benyoucef Benkhedda, Alger 1, Service de Neurologie CHU Mustapha, Algérie., Tazir M; Laboratoire de Recherche en Neurosciences Université Benyoucef Benkhedda, Alger 1, Service de Neurologie CHU Mustapha, Algérie., Ali Pacha L; Laboratoire de Recherche en Neurosciences Université Benyoucef Benkhedda, Alger 1, Service de Neurologie CHU Mustapha, Algérie., Kacem I; Department of Neurology, LR18SP03, Clinical Investigation Center of Neurosciences and Mental Health , Universitary Hospital Razi-Mannouba, Tunis, Tunisia, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Gouider R; Department of Neurology, LR18SP03, Clinical Investigation Center of Neurosciences and Mental Health , Universitary Hospital Razi-Mannouba, Tunis, Tunisia, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Henning F; Division of Neurology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa., Basse A; Neurology Department, CHNU Fann, UCAD, Dakar, Senegal., Cisse O; Neurology Department, CHNU Fann, UCAD, Dakar, Senegal., Balogou AK; Neurology Department, CHU Campus Université de Lomé., Kombate D; Neurology Department, CHU Campus Université de Lomé., Agbetou M; Faculty of Health Sciences, Laboratory of Chronic and Neurologic Diseases Epidemiology, University of Abomey-Calavi, Cotonou, Bénin; Neurology Unit, CNHU Cotonou, Cotonou, Bénin., Houinato D; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.; Faculty of Health Sciences, Laboratory of Chronic and Neurologic Diseases Epidemiology, University of Abomey-Calavi, Cotonou, Bénin; Neurology Unit, CNHU Cotonou, Cotonou, Bénin., Gnonlonfoun DD; Faculty of Health Sciences, Laboratory of Chronic and Neurologic Diseases Epidemiology, University of Abomey-Calavi, Cotonou, Bénin; Neurology Unit, CNHU Cotonou, Cotonou, Bénin., Millogo A; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.; Neurology Department, CHU Sourô Sanou, Bobo-Dioulasso, Université Joseph Ki- Zerbo Burkina Faso, and., Agba T; Université de Lomé, Togo., Belo M; Université de Lomé, Togo., Sengxeu N; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France., Hamidou B; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France., Preux PM; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France., Benoit M; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France., Couratier P; INSERM, Univ. Limoges, CHU Limoges, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.; Department of Neurology, CHU Limoges, Centre de Référence SLA et autres maladies du neurone moteur, Limoges, France.
Jazyk: angličtina
Zdroj: Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2022 May; Vol. 23 (3-4), pp. 279-283. Date of Electronic Publication: 2021 Aug 28.
DOI: 10.1080/21678421.2021.1961806
Abstrakt: Objective: To assess the availability of health workers and medications for clinical management of amyotrophic lateral sclerosis (ALS) in African hospital centers. Availability and affordability analyses of disease-modifying treatments were performed. Methods : A multicenter observational study involving African hospitals was conducted. A standard questionnaire was developed based on the European Federation of the Neurological Societies (EFNS) guidelines. We collected data on multidisciplinary care and availability of medicines. The availability and affordability were evaluated according to the WHO guidelines. Results : Nine hospital centers from eight African countries participated. We observed a low degree of implementation of multidisciplinary care in ALS management. Riluzole was only available in centers from South Africa, Senegal, Tunisia, and Togo. This treatment was unaffordable and the adjusted price was highly variable among countries. The cost of riluzole was partly or fully covered by patients, which implies a substantial economic burden. Conclusion : Our findings strengthen the need to promote multidisciplinary care in the clinical management of ALS in Africa. Disease-modifying medication should be both available and affordable. Local and international collaboration is needed to improve ALS health care access in Africa.
Databáze: MEDLINE
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