Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.
| Autor: | Biegański P; Department of Organic Chemistry, Faculty of Chemistry, University of Łódź Tamka 12 91-403 Łódź Poland kondor15@wp.pl konrad.kowalski@chemia.uni.lodz.pl +48-42-635-5759., Szczupak Ł; Department of Organic Chemistry, Faculty of Chemistry, University of Łódź Tamka 12 91-403 Łódź Poland kondor15@wp.pl konrad.kowalski@chemia.uni.lodz.pl +48-42-635-5759., Arruebo M; Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza Zaragoza 50009 Spain.; Department of Chemical Engineering, University of Zaragoza, Campus Río Ebro - Edificio I + D, C/Poeta Mariano Esquillor S/N 50018 Zaragoza Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN 28029 Madrid Spain., Kowalski K; Department of Organic Chemistry, Faculty of Chemistry, University of Łódź Tamka 12 91-403 Łódź Poland kondor15@wp.pl konrad.kowalski@chemia.uni.lodz.pl +48-42-635-5759. |
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| Jazyk: | angličtina |
| Zdroj: | RSC chemical biology [RSC Chem Biol] 2021 Jan 26; Vol. 2 (2), pp. 368-386. Date of Electronic Publication: 2021 Jan 26 (Print Publication: 2021). |
| DOI: | 10.1039/d0cb00218f |
| Abstrakt: | Rising bacterial antibiotic resistance is a global threat. To deal with it, new antibacterial agents and antiseptic materials need to be developed. One alternative in this quest is the organometallic derivatization of well-established antibacterial drugs and also the fabrication of advanced metal-based materials having antibacterial properties. Metal-based agents and materials often show new modes of antimicrobial action which enable them to overcome drug resistance in pathogenic bacterial strains. This review summarizes recent (2017-2020) progress in the field of organometallic-derived antibacterial drugs and metal-based materials having antibacterial activity. Specifically, it covers organometallic derivatives of antibacterial drugs including β-lactams, ciprofloxacin, isoniazid, trimethoprim, sulfadoxine, sulfamethoxazole, and ethambutol as well as non-antibacterial drugs like metformin, phenformin and aspirin. Recent advances and reported clinical trials in the use of metal-based nanomaterials as antibiofouling coatings on medical devices, as photocatalytic agents in indoor air pollutant control, and also as photodynamic/photothermal antimicrobial agents are also summarized. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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