Distribution, metabolism, excretion, and toxicity of implanted silver: a review.

Autor: Hadrup N; National Research Centre for the Working Environment, Copenhagen, Denmark., Sharma AK; Division for Diet, Disease Prevention and Toxicology, Group for Chemical Risk Assessment and GMO, National Food Institute, Technical University of Denmark, Lyngby, Denmark., Jacobsen NR; National Research Centre for the Working Environment, Copenhagen, Denmark., Loeschner K; Division for Food Technology, Research Group for Analytical Food Chemistry, National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Jazyk: angličtina
Zdroj: Drug and chemical toxicology [Drug Chem Toxicol] 2022 Sep; Vol. 45 (5), pp. 2388-2397. Date of Electronic Publication: 2021 Aug 30.
DOI: 10.1080/01480545.2021.1950167
Abstrakt: Some implantable medical devices contain silver. We aimed to assess at what amount implanted silver becomes toxic. Silver was elevated in bodily fluids and tissues surrounding silver-containing implants. Silver released from implants also distributes to blood and other tissues; there is evidence to suggest silver can pass the blood-brain-barrier. Silver can be deposited as nano-sized particles in various tissues. Such particles, in addition to silver, often contain other elements too, e.g., selenium and sulfur. Silver released from implants seems to stay in the body for long periods (years). Reported excretion pathways following implantation are urinary and fecal ones. Reported toxicological effects were virtually all local reactions surrounding the implants. Argyria is a blue-gray discoloration of the skin due to deposited silver granules. Localized argyria has been described after the implantation of acupuncture needles and silver-coated prostheses, although the presence of silver was tested only for and shown in the former. Other toxicological effects include local tissue reactivity and examples of neurotoxic and vascular effects. We did not include genotoxicity studies in the present publication as we recently evaluated silver to be genotoxic. Carcinogenicity studies were absent. We conclude that local toxicity of implanted silver can be foreseen in some situations.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje