The impact of CNS-directed treatment on quality of life in childhood cancer survivors.

Autor: Lipak KG; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Rausch JR; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA., Fisher RS; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Prussien KV; Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA., Clark OE; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Kenney AE; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Himelhoch AC; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Olshefski RS; Department of Pediatrics, The Ohio State University, Columbus, OH, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH, USA., Nahata L; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA.; Division of Endocrinology, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA., Vannatta K; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA.; Department of Psychology, The Ohio State University, Columbus, OH, USA., Compas BE; Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA., Gerhardt CA; Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. cynthia.gerhardt@nationwidechildrens.org.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA. cynthia.gerhardt@nationwidechildrens.org.; Department of Psychology, The Ohio State University, Columbus, OH, USA. cynthia.gerhardt@nationwidechildrens.org.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2022 Mar; Vol. 31 (3), pp. 817-829. Date of Electronic Publication: 2021 Aug 29.
DOI: 10.1007/s11136-021-02984-1
Abstrakt: Purpose: Pediatric cancer survivors may have lower quality of life (QoL), but most research has assessed outcomes either in treatment or long-term survivorship. We focused on early survivorship (i.e., 3 and 5 years post-diagnosis), examining the impact of CNS-directed treatment on child QoL, as well as sex and age at diagnosis as potential moderators.
Methods: Families of children with cancer (ages 5-17) were recruited at diagnosis or relapse (N = 336). Survivors completed the PedsQL at 3 (n = 96) and 5 years (n = 108), along with mothers (101 and 105, respectively) and fathers (45 and 53, respectively). The impact of CNS treatment, sex, and age at diagnosis on child QoL was examined over both time since diagnosis and time since last treatment using mixed model analyses.
Results: Parent-report of the child's total QoL was in the normative range and stable between 3 and 5 years when examining time since diagnosis, while child reported QoL improved over time (p = 0.04). In terms of time since last treatment, mother and child both reported the child's QoL improved over time (p = 0.0002 and p = 0.0006, respectively). Based on parent-report, males with CNS-directed treatment had lower total QoL than females and males who did not receive CNS-directed treatment. Age at diagnosis did not moderate the impact of treatment type on total QoL.
Conclusions: Quality of life (QoL) in early survivorship may be low among males who received CNS-directed treatment. However, this was only evident on parent-report. Interventions to improve child QoL should focus on male survivors who received CNS-directed treatment, as well as females regardless of treatment type.
(© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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