Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community.

Autor: Keating D; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA. Electronic address: dmk13@bu.edu., Zundel CG; Boston University School of Medicine, Behavioral Neuroscience Program, 72 East Concord St., Boston, MA 02118, USA. Electronic address: cgzundel@bu.edu., Abreu M; Dr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA; Geriatric Research Education and Clinical Center, Miami VA Medical Center, Miami, FL 33125, USA. Electronic address: mabreu1@nova.edu., Krengel M; Boston University School of Medicine, Department of Neurology, 72 East Concord St., Boston, MA 02118, USA. Electronic address: mhk@bu.edu., Aenlle K; Dr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA; Geriatric Research Education and Clinical Center, Miami VA Medical Center, Miami, FL 33125, USA. Electronic address: kaenlle@nova.edu., Nichols MD; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA., Toomey R; Department of Psychological and Brain Sciences, College of Arts and Sciences, Boston University, 900 Commonwealth Ave., Boston, MA, USA. Electronic address: toomey@bu.edu., Chao LL; San Francisco Veterans Affairs Health Care System, University of California, San Francisco, CA 94143, USA. Electronic address: linda.chao@ucsf.edu., Golier J; James J. Peters VA Medical Center, OOMH-526, 130 West Kingsbridge Road, Bronx, NY 10468, USA; Psychiatry Department, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029, USA. Electronic address: julia.golier@va.gov., Abdullah L; Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, USA; Open University, Milton Keynes, United Kingdom; James A. Haley Veterans' Hospital, Tampa, FL, USA. Electronic address: labdullah@roskampinstitute.org., Quinn E; Boston University School of Public Health, Department of Biostatistics, 715 Albany St., Boston, MA 02118, USA. Electronic address: eq@bu.edu., Heeren T; Boston University School of Public Health, Department of Biostatistics, 715 Albany St., Boston, MA 02118, USA. Electronic address: tch@bu.edu., Groh JR; Boston University School of Medicine, Behavioral Neuroscience Program, 72 East Concord St., Boston, MA 02118, USA. Electronic address: jengroh@bu.edu., Koo BB; Boston University School of Medicine, Department of Anatomy and Neurobiology, 72 East Concord St., Boston, MA 02118, USA. Electronic address: bbkoo@bu.edu., Killiany R; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA; Boston University School of Medicine, Department of Neurology, 72 East Concord St., Boston, MA 02118, USA; Boston University School of Medicine, Department of Anatomy and Neurobiology, 72 East Concord St., Boston, MA 02118, USA. Electronic address: killiany@bu.edu., Loggia ML; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: marco.loggia@mgh.harvard.edu., Younger J; Neuroinflammation, Pain & Fatigue Lab, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: younger@uab.edu., Baraniuk J; Department of Medicine, Georgetown University, Washington, DC, USA. Electronic address: baraniuj@georgetown.edu., Janulewicz P; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA. Electronic address: paj@bu.edu., Ajama J; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA. Electronic address: ajamaj@bu.edu., Quay M; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA. Electronic address: quaym@bu.edu., Baas PW; Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA 19129, USA. Electronic address: pwb22@drexel.edu., Qiang L; Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA 19129, USA. Electronic address: lq24@drexel.edu., Conboy L; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lisa_conboy@hms.haravard.edu., Kokkotou E; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ekokkoto@bidmc.harvard.edu., O'Callaghan JP; Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address: jdo5@cdc.gov., Steele L; Baylor College of Medicine Neuropsychiatry Division, Department of Psychiatry and Behavioral Sciences, Houston, TX 77030, USA. Electronic address: Lea.Steele@bcm.edu., Klimas N; Dr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA; Geriatric Research Education and Clinical Center, Miami VA Medical Center, Miami, FL 33125, USA. Electronic address: nklimas@bu.edu., Sullivan K; Boston University School of Public Health, Department of Environmental Health, 715 Albany St. T4W, Boston, MA 02118, USA. Electronic address: tty@bu.edu.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Nov 01; Vol. 284, pp. 119903. Date of Electronic Publication: 2021 Aug 26.
DOI: 10.1016/j.lfs.2021.119903
Abstrakt: Aims: Gulf War Illness (GWI), a chronic debilitating disorder characterized by fatigue, joint pain, cognitive, gastrointestinal, respiratory, and skin problems, is currently diagnosed by self-reported symptoms. The Boston Biorepository, Recruitment, and Integrative Network (BBRAIN) is the collaborative effort of expert Gulf War Illness (GWI) researchers who are creating objective diagnostic and pathobiological markers and recommend common data elements for GWI research.
Main Methods: BBRAIN is recruiting 300 GWI cases and 200 GW veteran controls for the prospective study. Key data and biological samples from prior GWI studies are being merged and combined into retrospective datasets. They will be made available for data mining by the BBRAIN network and the GWI research community. Prospective questionnaire data include general health and chronic symptoms, demographics, measures of pain, fatigue, medical conditions, deployment and exposure histories. Available repository biospecimens include blood, plasma, serum, saliva, stool, urine, human induced pluripotent stem cells and cerebrospinal fluid.
Key Findings: To date, multiple datasets have been merged and combined from 15 participating study sites. These data and samples have been collated and an online request form for repository requests as well as recommended common data elements have been created. Data and biospecimen sample requests are reviewed by the BBRAIN steering committee members for approval as they are received.
Significance: The BBRAIN repository network serves as a much needed resource for GWI researchers to utilize for identification and validation of objective diagnostic and pathobiological markers of the illness.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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