The promise of the gut microbiome as part of individualized treatment strategies.

Autor: Schupack DA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Mars RAT; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Voelker DH; Division of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Abeykoon JP; Division of Hematology and Oncology, Mayo Clinic, Rochester, MN, USA., Kashyap PC; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. kashyap.purna@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. kashyap.purna@mayo.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2022 Jan; Vol. 19 (1), pp. 7-25. Date of Electronic Publication: 2021 Aug 27.
DOI: 10.1038/s41575-021-00499-1
Abstrakt: Variability in disease presentation, progression and treatment response has been a central challenge in medicine. Although variability in host factors and genetics are important, it has become evident that the gut microbiome, with its vast genetic and metabolic diversity, must be considered in moving towards individualized treatment. In this Review, we discuss six broad disease groups: infectious disease, cancer, metabolic disease, cardiovascular disease, autoimmune or inflammatory disease, and allergic and atopic diseases. We highlight current knowledge on the gut microbiome in disease pathogenesis and prognosis, efficacy, and treatment-related adverse events and its promise for stratifying existing treatments and as a source of novel therapies. The Review is not meant to be comprehensive for each disease state but rather highlights the potential implications of the microbiome as a tool to individualize treatment strategies in clinical practice. Although early, the outlook is optimistic but challenges need to be overcome before clinical implementation, including improved understanding of underlying mechanisms, longitudinal studies with multiple data layers reflecting gut microbiome and host response, standardized approaches to testing and reporting, and validation in larger cohorts. Given progress in the microbiome field with concurrent basic and clinical studies, the microbiome will likely become an integral part of clinical care within the next decade.
(© 2021. Springer Nature Limited.)
Databáze: MEDLINE
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