The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response.

Autor: Botti-Lodovico Y; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Nair P; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Nosamiefan D; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Stremlau M; Equator Labs Incorporated, Washington, DC 20011, USA., Schaffner S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Agignoae SV; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Harvard Kennedy School, Cambridge, MA 02138, USA., Aiyepada JO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Ajogbasile FV; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Akpede GO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria., Alhasan F; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Asogun DA; Ambrose Alli University, Ekpoma, Edo State, Nigeria., Ayodeji OO; Federal Medical Centre, Owo, Ondo State, Nigeria., Badiane AS; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Barnes K; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Bauer MR; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., Bell-Kareem A; Tulane University Medical Center, New Orleans, LA 70112, USA., Benard ME; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Benevolence EO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Blessing O; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Boehm CK; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA., Boisen ML; Zalgen Labs, Germantown, MD 20876, USA., Bond NG; Tulane University Medical Center, New Orleans, LA 70112, USA., Branco LM; Zalgen Labs, Germantown, MD 20876, USA., Butts MJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Carter A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Colubri A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; University of Massachusetts Medical School, Worcester, MA 01605, USA., Deme AB; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., DeRuff KC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Diédhiou Y; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Edamhande AP; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Elhamoumi S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Engel EJ; Tulane University Medical Center, New Orleans, LA 70112, USA., Eromon P; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Fallah M; Refuge Place International, Bassa Town, Lower Johnsonville, Liberia., Folarin OA; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Fry B; Fathom Information Design, Boston, MA 02114, USA., Garry R; Tulane University Medical Center, New Orleans, LA 70112, USA., Gaye A; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Gbakie M; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Gevao SM; University of Sierra Leone, Freetown, Sierra Leone., Gionet G; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Gladden-Young A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Goba A; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Gomis JF; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Happi AN; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Houghton M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Ihekwuazu C; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Iruolagbe CO; Department of Internal Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Jackson J; Dimagi, Inc., Cambridge, MA 02139, USA., Jalloh S; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Johnson J; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Kanneh L; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Kayode A; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Kemball M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Kingsley OC; Department of Medical Microbiology, Alex-Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Ebonyi, Nigeria., Koroma V; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone., Kotliar D; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Mehta S; Department of Critical Care Medicine, University of Maryland Medical Center, Baltimore, MA 21201, USA., Metsky HC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Michael A; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Mirhashemi ME; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Modjarrad K; Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Momoh M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.; Eastern Polytechnic College, Kenema, Sierra Leone., Myhrvold CA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA., Naregose OG; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Ndiaye T; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Ndiaye M; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Ndiaye A; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Normandin E; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Odia I; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Oguzie JU; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Okogbenin SA; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Okokhere PO; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Okolie J; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Olawoye IB; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Olumade TJ; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Oluniyi PE; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Omoregie O; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.; West African Examinations Council, Yaba, Lagos State, Nigeria., Park DJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Paye MF; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Petros B; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA.; Harvard/MIT MD-PhD Program, Boston, MA 02115, USA., Philippakis AA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Priscilla A; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria., Ricks A; MASS Design Group, Boston, MA 02116, USA.; Yale School of Architecture, New Haven, CT 06511, USA., Rimoin A; Department of Epidemiology, Jonathan and Karing Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Sandi JD; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Schieffelin JS; Section of Infectious Disease, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA., Schreiber M; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Seck MC; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Siddiqui S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Siddle K; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Smither AR; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Sy M; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Sy N; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Tomkins-Tinch CH; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Tomori O; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Ugwu C; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Uwanibe JN; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Uyigue EA; Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria., Victoria DI; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Ikorodu General Hospital, Ikorodu, Lagos State, Nigeria., Vinzé A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Vodzak ME; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Welch N; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., Wurie HI; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Zoumarou D; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., Grant DS; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Ndiaye D; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.; Université Cheikh Anta Diop, BP 5005, Dakar, Senegal., MacInnis B; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Sabeti PC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Happi C; African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2021 Aug 13; Vol. 13 (8). Date of Electronic Publication: 2021 Aug 13.
DOI: 10.3390/v13081605
Abstrakt: While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz's critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
Databáze: MEDLINE
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