The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement.

Autor: Kim JH; Department of Urology, Soonchunhyang University School of Medicine, Seoul 04404, Korea.; Department of Microbiology, Soonchunhyang University School of Medicine, Seoul 04404, Korea., Yang HJ; Department of Urology, Soonchunhyang University School of Medicine, Cheonan 31151, Korea., Lee CH; Department of Urology, Soonchunhyang University School of Medicine, Cheonan 31151, Korea., Jeon YS; Department of Urology, Soonchunhyang University School of Medicine, Cheonan 31151, Korea., Park JJ; Department of Urology, Soonchunhyang University School of Medicine, Seoul 04404, Korea., Lee KW; Department of Urology, Soonchunhyang University School of Medicine, Bucheon 14584, Korea., Kim JH; Department of Urology, Soonchunhyang University School of Medicine, Gumi 39371, Korea., Park SY; Department of Data Innovation, Soonchunhyang University Seoul Hospital, Seoul 04404, Korea.; Department of Applied Statistics, Chung-Ang University, Seoul 06974, Korea., Song SJ; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan 31151, Korea.; Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, Korea., Kim YH; Department of Pathology, Soonchunhyang University School of Medicine, Seoul 04404, Korea., Moon AR; Department of Pathology, Soonchunhyang University School of Medicine, Bucheon 14584, Korea., Lee JH; Department of Pathology, Soonchunhyang University School of Medicine, Cheonan 31151, Korea., Song YS; Department of Urology, Soonchunhyang University School of Medicine, Seoul 04404, Korea.
Jazyk: angličtina
Zdroj: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2021 Aug 08; Vol. 14 (8). Date of Electronic Publication: 2021 Aug 08.
DOI: 10.3390/ph14080778
Abstrakt: Background: The mTOR signaling pathway is inactivated by AMPK's tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers.
Methods: This study investigated the clinical data about prostate cancer. Examination was also carried out into tissue microarrays (TMA) of human prostate cancer ( n = 382) and adjacent non-neoplastic tissues around prostate cancer ( n = 61). The TMA slides were incubated with antibodies against UBE2O, and the cores were scored by the pathologist blind to cancer results.
Results: Very strong positive correlations were identified between the expression of UBE2O staining and high PSA and pathological stage of prostate cancer. Cox's proportional hazard analysis established correlations between the following: (1) positive surgical margin and biochemical recurrence free survival, (2) PSA grade and clinical recurrence free survival, (3) regional lymph node positive and clinical recurrence free survival, (4) adjuvant treatment and overall survival, and (5) pathological T stage and overall survival.
Conclusion: There is a positive correlation between the expression of UBE2O staining and prognosis for prostate cancer. Thus, a prostate cancer prognosis can be assessed with the expression of UBE2O staining.
Databáze: MEDLINE
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