An Injectable Meta-Biomaterial: From Design and Simulation to In Vivo Shaping and Tissue Induction.

Autor: Béduer A; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, Geneva, CH-1211, Switzerland.; School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), LMIS4. BM, Station 17, Lausanne, CH-1015, Switzerland., Bonini F; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, Geneva, CH-1211, Switzerland., Verheyen CA; School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), LMIS4. BM, Station 17, Lausanne, CH-1015, Switzerland., Genta M; School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), LMIS4. BM, Station 17, Lausanne, CH-1015, Switzerland., Martins M; Volumina-Medical SA, Route de la Corniche 5, Epalinges, CH-1066, Switzerland., Brefie-Guth J; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, Geneva, CH-1211, Switzerland., Tratwal J; Department of Biomedical Sciences, Laboratory of Regenerative Hematopoiesis, University of Lausanne, Rue du Bugnon 27, Lausanne, CH-1011, Switzerland., Filippova A; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, Geneva, CH-1211, Switzerland., Burch P; School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), LMIS4. BM, Station 17, Lausanne, CH-1015, Switzerland.; Volumina-Medical SA, Route de la Corniche 5, Epalinges, CH-1066, Switzerland., Naveiras O; Department of Biomedical Sciences, Laboratory of Regenerative Hematopoiesis, University of Lausanne, Rue du Bugnon 27, Lausanne, CH-1011, Switzerland.; CHUV, Hematology Service, Department of Oncology, Rue du Bugnon 46, Lausanne, CH-1011, Switzerland., Braschler T; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, Geneva, CH-1211, Switzerland.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2021 Oct; Vol. 33 (41), pp. e2102350. Date of Electronic Publication: 2021 Aug 27.
DOI: 10.1002/adma.202102350
Abstrakt: A novel type of injectable biomaterial with an elastic softening transition is described. The material enables in vivo shaping, followed by induction of 3D stable vascularized tissue. The synthesis of the injectable meta-biomaterial is instructed by extensive numerical simulation as a suspension of irregularly fragmented, highly porous sponge-like microgels. The irregular particle shape dramatically enhances yield strain for in vivo stability against deformation. Porosity of the particles, along with friction between internal surfaces, provides the elastic softening transition. This emergent metamaterial property enables the material to reversibly change stiffness during deformation, allowing native tissue properties to be matched over a wide range of deformation amplitudes. After subcutaneous injection in mice, predetermined shapes can be sculpted manually. The 3D shape is maintained during excellent host tissue integration, with induction of vascular connective tissue that persists to the end of one-year follow-up. The geometrical design is compatible with many hydrogel materials, including cell-adhesion motives for cell transplantation. The injectable meta-biomaterial therefore provides new perspectives in soft tissue engineering and regenerative medicine.
(© 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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