Physiochemical characterization of highly biocompatible, and colloidal LaF 3 :Yb/Er upconversion nanoparticles.

Autor: Ansari AA; King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, Saudi Arabia. amustaqeemahmad@ksu.edu.sa., Parchur AK; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, 53226, USA., Labis JP; King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, Saudi Arabia., Shar MA; King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, Saudi Arabia.
Jazyk: angličtina
Zdroj: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2021 Sep; Vol. 20 (9), pp. 1195-1208. Date of Electronic Publication: 2021 Aug 27.
DOI: 10.1007/s43630-021-00092-0
Abstrakt: Highly colloidal upconversion nanoparticles (UCNPs) were synthesized at low temperatures by the thermal decomposition process. The structure, morphology, crystallinity, surface chemistry, and optical properties were systematically optimized and studied through various spectroscopic techniques. X-ray diffraction (XRD) patterns have shown the formation of single-phase, highly purified, well-crystalline, hexagonal LaF 3 NPs, while the TEM micrographs show small, irregular sizes, spherically shaped, and aggregated polycrystalline UCNPs with an average crystalline size of about 8-15 nm. The Negative Zeta Potential value exhibits good biocompatibility of the UCNPs, which supports the idea that surface-anchored hydroxyl groups facilitate the stabilization of the NPs in aqueous media, as well as enhance biomolecules' tagging efficiency. The absorption spectrum, Zeta Potential, and hydrodynamic size that were measured in aqueous media illustrate excellent dispersibility, colloidal stability, biocompatibility, and cytotoxicity character of the UCNPs. Zeta potential and MTT assay studies illustrated high biocompatibility, it could be due to the surface-anchored hydroxyl groups. The nanoproduct demonstrates an excellent UC luminescence spectrum (i.e., prominent green emission 4 S 3/2  →  4 I/ 15/2 ) upon irradiation by the 980-nm laser diode. TEM micrographs, further, revealed that this optically active material with aqueous sensitivities, porous crystal structure, and excellent UCNPs, could be a favorable candidate for potential photonics-based bio-related applications.
(© 2021. The Author(s), under exclusive licence to European Photochemistry Association, European Society for Photobiology.)
Databáze: MEDLINE
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