Trans-Ethnic Meta-Analysis of Interactions Between Genetics and Early-Life Socioeconomic Context on Memory Performance and Decline in Older Americans.

Autor:	Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA., Kho M; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA., Rumfelt KE; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA., Yu M; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA., Mitchell C; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Nov 21; Vol. 77 (11), pp. 2248-2256.
DOI:	10.1093/gerona/glab255
Abstrakt:	Background: Later-life cognitive function is influenced by genetics as well as early- and later-life socioeconomic context. However, few studies have examined the interaction between genetics and early childhood factors. Methods: Using gene-based tests (interaction sequence kernel association test [iSKAT]/iSKAT optimal unified test), we examined whether common and/or rare exonic variants in 39 gene regions previously associated with cognitive performance, dementia, and related traits had an interaction with childhood socioeconomic context (parental education and financial strain) on memory performance or decline in European ancestry (EA, N = 10 468) and African ancestry (AA, N = 2 252) participants from the Health and Retirement Study. Results: Of the 39 genes, 22 in EA and 19 in AA had nominally significant interactions with at least one childhood socioeconomic measure on memory performance and/or decline; however, all but one (father's education by solute carrier family 24 member 4 [SLC24A4] in AA) were not significant after multiple testing correction (false discovery rate [FDR] < .05). In trans-ethnic meta-analysis, 2 genes interacted with childhood socioeconomic context (FDR < .05): mother's education by membrane-spanning 4-domains A4A (MS4A4A) on memory performance, and father's education by SLC24A4 on memory decline. Both interactions remained significant (p < .05) after adjusting for respondent's own educational attainment, apolipoprotein-ε4 allele (APOE ε4) status, lifestyle factors, body mass index, and comorbidities. For both interactions in EA and AA, the genetic effect was stronger in participants with low parental education. Conclusions: Examination of common and rare variants in genes discovered through genome-wide association studies shows that childhood context may interact with key gene regions to jointly impact later-life memory function and decline. Genetic effects may be more salient for those with lower childhood socioeconomic status. (© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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